比较各种基于木瓜蛋白酶的酶制剂与2.4%次氯酸钠凝胶在化学机械去龋中的疗效：一项随机对照试验。

Comparing efficacies of various papain-based enzyme agents and 2.4% sodium hypochlorite gel in chemomechanical caries removal: a randomized controlled trial.

作者信息

Alsayed M H D Baraa, Karkoutly Mawia, Achour Hassan, Abboud Souad

机构信息

Department of Restorative Dentistry and Endodontics, Damascus University, Damascus, Syrian Arab Republic.

Department of Pediatric Dentistry, Damascus University, Damascus, Syrian Arab Republic.

出版信息

BDJ Open. 2024 Sep 4;10(1):70. doi: 10.1038/s41405-024-00258-9.

DOI:10.1038/s41405-024-00258-9

PMID:39231949

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11375084/

Abstract

OBJECTIVE

This study aimed to evaluate and compare the efficacies of Papacarie Duo gel, Brix 3000, Selecti-Solve gel, 2.4% sodium hypochlorite gel, and conventional rotary-mechanical method in caries removal and to evaluate the patient comfort.

METHODS

It was a single-blinded, randomized, parallel-group, active-controlled trial with five arms. It was conducted at the Department of Restorative Dentistry and Endodontics, Damascus University. Seventy-five specimens were randomly allocated into five groups: chemomechanical caries removal (CMCR) using Selecti-Solve gel (G1), BRIX3000 (G2), Papacarie DUO gel (G3), or 2.4% sodium hypochlorite gel (G4), and caries excavation using conventional rotary-mechanical method (G5) (control group). The trial considered healthy patients aged 18-40. Permanent molars with class I carious lesions extending to the middle third of dentin with no pulpal and/or periodontal pathology were included. The efficacy of caries removal was considered the primary outcome measure, and the secondary outcome measures were treatment time, volumetric measurement of the cavity, and pain assessment.

RESULTS

The majority (73.30%) of cases from BRIX3000 and conventional rotary-mechanical method groups showed complete caries removal (p = 0.982). The mean time of caries removal was the highest (17.45 ± 4.42) in the 2.4% sodium hypochlorite gel group (p < 0.05), and the lowest (6.33 ± 1.69) was in the conventional rotary-mechanical method group (p < 0.05). The mean cavity volume was the highest (18.97 ± 9.76) in the Papacarie DUO gel group, and the lowest (14.87 ± 4.76) was in the 2.4% sodium hypochlorite gel group (p = 0.506). The conventional rotary-mechanical group exhibited the highest mean score (5.40 ± 1.72) of pain (p < 0.05). However, the mean score (2.67 ± 1.11) of pain reported reduced in the BRIX3000 group.

CONCLUSIONS

CMCR agents could be a potential substitute for conventional rotary instrumentation methods, taking into account the long working time.

摘要

目的

本研究旨在评估和比较帕帕卡里 Duo 凝胶、Brix 3000、Selecti - Solve 凝胶、2.4%次氯酸钠凝胶以及传统旋转机械方法在龋病去除方面的疗效，并评估患者的舒适度。

方法

这是一项单盲、随机、平行组、活性对照试验，分为五个组。试验在大马士革大学修复牙科与牙髓病科进行。75 个样本被随机分为五组：使用 Selecti - Solve 凝胶进行化学机械性龋病去除（CMCR）（G1 组）、Brix3000（G2 组）、帕帕卡里 DUO 凝胶（G3 组）或 2.4%次氯酸钠凝胶（G4 组），以及使用传统旋转机械方法进行龋洞挖掘（G5 组）（对照组）。该试验纳入年龄在 18 - 40 岁的健康患者。纳入的恒牙为 I 类龋损，龋损延伸至牙本质中层且无牙髓和/或牙周病变。龋病去除的疗效被视为主要观察指标，次要观察指标为治疗时间、龋洞的体积测量和疼痛评估。

结果

Brix3000 组和传统旋转机械方法组的大多数病例（73.30%）显示龋病完全去除（p = 0.982）。2.4%次氯酸钠凝胶组的龋病去除平均时间最长（17.45 ± 4.42）（p < 0.05），传统旋转机械方法组最短（6.33 ± 1.69）（p < 0.05）。帕帕卡里 DUO 凝胶组的平均龋洞体积最大（18.97 ± 9.76），2.4%次氯酸钠凝胶组最小（14.87 ± 4.76）（p = 0.506）。传统旋转机械组的疼痛平均评分最高（5.40 ± 1.72）（p < 0.05）。然而，Brix3000 组报告的疼痛平均评分降低（2.67 ± 1.11）。