Department of Ultrasound, China-Japan Union Hospital of Jilin University, No. 126, Xian Tai Street, Changchun and Jilin, 130000, China.
J Cancer Res Clin Oncol. 2023 Apr;149(4):1645-1656. doi: 10.1007/s00432-022-04190-z. Epub 2022 Jul 13.
Tumor immunotherapy has become an important means of tumor therapy by enhancing the immune response and triggering the activation of immune cells. However, currently, only a small number of patients respond to immunotherapy alone, and patients may experience immune-related adverse events (irAEs) during the course of treatment. Sonodynamic therapy (SDT) can produce cytotoxic substances to tumor tissue, induce apoptosis and enhance immunity. SDT combined with immunotherapy is considered a promising strategy for cancer treatment. In this mini review, we summarize the role of SDT in immunotherapy in recent years, including the application of SDT-triggered immunotherapy and the combination of SDT and immunotherapy.
肿瘤免疫疗法通过增强免疫反应和触发免疫细胞的激活，已成为肿瘤治疗的重要手段。然而，目前只有少数患者对免疫疗法有反应，并且患者在治疗过程中可能会经历免疫相关的不良反应（irAEs）。声动力学疗法（SDT）可以向肿瘤组织产生细胞毒性物质，诱导细胞凋亡并增强免疫力。SDT 联合免疫疗法被认为是癌症治疗的一种有前途的策略。在这篇迷你综述中，我们总结了近年来 SDT 在免疫治疗中的作用，包括 SDT 触发免疫治疗的应用以及 SDT 与免疫治疗的联合应用。
