District Hospital of Orthopedics and Trauma Surgery in Piekary Śląskie, Piekary Śląskie, Poland.
Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland.
Med Sci Monit. 2022 Jul 14;28:e936335. doi: 10.12659/MSM.936335.
BACKGROUND Oxidative stress is a disruption of the pro-oxidative-antioxidant balance, caused by excessive production or ineffective removal of reactive oxygen species. MATERIAL AND METHODS The study included 42 male patients aged 38 to 69 years. The first group consisted of 21 men with osteoarthritis after primary hip arthroplasty using the Smith & Nephew Birmingham Hip Resurfacing implant. The second group included 21 men after hip arthroplasty using the femoral neck SPIRON K-implant. In both groups, concentrations of ions, the antioxidant system in the blood, and parameters of oxidative stress were evaluated twice. Clinical assessment using the Western Ontario and McMaster Universities Osteoarthritis Index, Harris Hip Score, and Short Form (12) Health Survey (SF-12) scales was performed. RESULTS Concentrations of metal ions in the blood and the level of oxidative stress were significantly higher in the resurfacing group than in the femoral neck arthroplasty group. The response of the antioxidant system was significantly greater in the femoral neck arthroplasty group. During clinical evaluation, groups did not show significant differences, with the exception of greater shortening of the operated limb and a lower score in the mental-sphere of the SF-12 scale in the resurfacing arthroplasty group. CONCLUSIONS Resurfacing hip arthroplasty increased oxidative stress, increased the concentration of metal ions, and did not affect alignment of the abbreviation of the operated limb. A significant improvement in the quality of life of patients in the mental sphere according to the SF-12 occurred after the application of resurfacing arthroplasty, in the first month after the procedure.
氧化应激是由于活性氧自由基的产生过多或清除无效而导致的促氧化-抗氧化平衡破坏。
该研究纳入了 42 名年龄在 38 至 69 岁的男性患者。第一组包括 21 名接受初次髋关节置换术（采用 Smith & Nephew Birmingham Hip Resurfacing 植入物）的男性骨关节炎患者。第二组包括 21 名接受股骨颈 SPIRON K 植入物髋关节置换术的男性患者。两组患者均两次评估血液中离子浓度、抗氧化系统和氧化应激参数。使用 Western Ontario and McMaster Universities Osteoarthritis Index、Harris Hip Score 和 Short Form (12) Health Survey (SF-12) 量表进行临床评估。
表面置换组血液中金属离子浓度和氧化应激水平显著高于股骨颈置换组。股骨颈置换组抗氧化系统的反应明显更大。在临床评估中，两组除了表面置换组的患肢缩短程度更大和 SF-12 量表心理领域评分较低外，无显著差异。
髋关节表面置换术增加了氧化应激，增加了金属离子的浓度，并且不会影响患肢的缩短。根据 SF-12，表面置换术后第一个月，患者的生活质量在心理领域显著改善。
