云南人群肺癌筛查中七种自身抗体 panel 的应用价值分析。
Application Value Analysis of Seven-Autoantibody Panel in the Lung Cancer Screening in Yunnan.
机构信息
Department of Medical Laboratory, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
出版信息
Comput Intell Neurosci. 2022 Jul 4;2022:2368155. doi: 10.1155/2022/2368155. eCollection 2022.
OBJECTIVE
To study the application value of seven-autoantibody (anti-CAGE, anti-GAGE7, anti-GBU4-5, anti-MAGE A1, anti-P53, and anti-PGP9.5, anti-SOX2) in lung cancer (LC) screening in Yunnan.
METHODS
The clinical data of 329 lung cancer patients and 202 nonlung cancer controls in the First People's Hospital of Yunnan Province from November 2018 to April 2022 were retrospectively analyzed. The detection results of anti-CAGE, anti-GAGE7, anti-GBU4-5, anti-MAGE A1, anti-P53, anti-PGP9.5, and anti-SOX2 were collected. The receiver operating curve (ROC) was used to analyze the value of these seven-autoantibody in the detection of LC alone and in combination, and the area under the curve (AUC), sensitivity, specificity, and cut-off values were calculated.
RESULTS
The levels of anti-CAGE, anti-GAGE7, anti-GBU4-5, anti-MAGE A1, anti-P53, anti-PGP9.5 and anti-SOX2 in LC patients were significantly higher than those in the controls, and the differences were statistically significant ( < 0.001). The AUC of anti-CAGE, anti-GAGE7, anti-GBU4-5, anti-MAGE A1, anti-P53, anti-PGP9.5, and anti-SOX2 for the diagnosis of LC were 0.586 (95% CI: 0.537-0.634, < 0.001), 0.620 (95% CI: 0.572-0.667, < 0.001), 0.570 (95% CI: 0.521-0.619, =0.007), 0.612 (95% CI: 0.563-0.660, < 0.007) 0.001), 0.561 (95% CI: 0.510-0.611, =0.019), 0.667 (95% CI: 0.619-0.715, < 0.001), 0.587 (95% CI: 0.538-0.636, < 0.001), respectively. The AUC of combined detection of LC was 0.719 (95% CI: 0.676-0.761, < 0.001). The positive rate of the combined detection of seven-autoantibody in the LC group was 48.02% (158/329), which was significantly higher than that of the control group (13.86% (28/202)), the difference was statistically significant ( = 64.183, < 0.001).
CONCLUSION
The individual detection and combined detection of the seven-autoantibody have a certain value in the diagnosis of LC in Yunnan, and it can provide a certain reference for clinical LC screening.
目的
研究七项自身抗体（抗 CAGE、抗 GAGE7、抗 GBU4-5、抗 MAGE A1、抗 P53、抗 PGP9.5 和抗 SOX2）在云南肺癌（LC）筛查中的应用价值。
方法
回顾性分析 2018 年 11 月至 2022 年 4 月云南省第一人民医院 329 例肺癌患者和 202 例非肺癌对照者的临床资料，收集抗 CAGE、抗 GAGE7、抗 GBU4-5、抗 MAGE A1、抗 P53、抗 PGP9.5 和抗 SOX2 的检测结果。采用受试者工作特征曲线（ROC）分析单独和联合检测这七种自身抗体在 LC 检测中的价值，计算曲线下面积（AUC）、敏感度、特异度和截断值。
结果
LC 患者的抗 CAGE、抗 GAGE7、抗 GBU4-5、抗 MAGE A1、抗 P53、抗 PGP9.5 和抗 SOX2 水平明显高于对照组，差异具有统计学意义（<0.001）。抗 CAGE、抗 GAGE7、抗 GBU4-5、抗 MAGE A1、抗 P53、抗 PGP9.5 和抗 SOX2 对 LC 的诊断 AUC 分别为 0.586（95%CI：0.537-0.634，<0.001）、0.620（95%CI：0.572-0.667，<0.001）、0.570（95%CI：0.521-0.619，=0.007）、0.612（95%CI：0.563-0.660，<0.007）、0.001）、0.561（95%CI：0.510-0.611，=0.019）、0.667（95%CI：0.619-0.715，<0.001）、0.587（95%CI：0.538-0.636，<0.001），联合检测 LC 的 AUC 为 0.719（95%CI：0.676-0.761，<0.001）。LC 组七种自身抗体联合检测的阳性率为 48.02%（158/329），明显高于对照组的 13.86%（28/202），差异具有统计学意义（=64.183，<0.001）。
结论
七种自身抗体的单项检测和联合检测对云南 LC 的诊断具有一定价值，可为临床 LC 筛查提供一定参考。
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