Rastogi Ayushi, Singh Abhilasha, Naik Kaustubh, Mishra Archana, Chaudhary Shilpi, Manohar Rajiv, Singh Parmar Avanish
Liquid Crystal Laboratory, Department of Physics, University of Lucknow, Lucknow 226007, Uttar Pradesh, India.
Department of Humanity and Applied Sciences (Physics), SMS College of Engineering, Institute of Technology, Lucknow 226001, Uttar Pradesh, India.
J Mol Liq. 2022 Sep 15;362:119795. doi: 10.1016/j.molliq.2022.119795. Epub 2022 Jul 8.
The COVID-19 is a pandemic caused by the SARS-CoV-2 virus, has instigated major health problems and prompted WHO to proclaim a worldwide medical emergency. The knowledge of SARS-CoV-2 fundamental structure, aetiology, its entrance mechanism, membrane hijacking and immune response against the virus, are important parameters to develop effective vaccines and medicines. Liquid crystals integrated nano-techniques and various nanoformulations were applied to tackle the severity of the virus. It was reported that nanoformulations have helped to enhance the effectiveness of presently accessible antiviral medicines or to elicit a fast immunological response against COVID-19 virus. Applications of liquid crystals, nanostructures, nanoformulations and nanotechnology in diagnosis, prevention, treatment and tailored vaccine administration against COVID-19 which will help in establishing the framework for a successful pandemic combat are reviewed. This review also focuses on limitations associated with liquid crystal-nanotechnology based systems and suggests the possible ways to address these limitations. Also, topical advancements in the ground of liquid crystals and nanostructures established diagnostics (nanosensor/biosensor) are discussed in detail.
新型冠状病毒肺炎（COVID-19）是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒引起的大流行病，引发了重大健康问题，并促使世界卫生组织宣布全球医疗紧急情况。了解SARS-CoV-2的基本结构、病因、进入机制、膜劫持以及针对该病毒的免疫反应，是开发有效疫苗和药物的重要参数。液晶集成纳米技术和各种纳米制剂被应用于应对该病毒的严重性。据报道，纳米制剂有助于提高目前可用抗病毒药物的有效性，或引发针对COVID-19病毒的快速免疫反应。本文综述了液晶、纳米结构、纳米制剂和纳米技术在COVID-19诊断、预防、治疗和定制疫苗接种中的应用，这将有助于建立成功抗击大流行的框架。本综述还关注基于液晶-纳米技术的系统的局限性，并提出解决这些局限性的可能方法。此外，还详细讨论了基于液晶和纳米结构的诊断（纳米传感器/生物传感器）领域的最新进展。
