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基于树脂中枞酸配体的铜（II）和钴（II）配合物：合成、表征及其对严重急性呼吸综合征冠状病毒2的抗菌和抗病毒活性

Copper(II) and Cobalt(II) Complexes Based on Abietate Ligands from Resin: Synthesis, Characterization and Their Antibacterial and Antiviral Activity against SARS-CoV-2.

作者信息

Correa Jamille de S, Primo Julia de O, Balaba Nayara, Pratsch Christoph, Werner Stephan, Toma Henrique E, Anaissi Fauze J, Wattiez Ruddy, Zanette Cristina M, Onderwater Rob C A, Bittencourt Carla

机构信息

Departament of Chemistry, Universidade Estadual do Centro-Oeste, UNICENTRO, Alameda Elio Antonio Dalla Vecchia, 838, Guarapuava 85040-167, PR, Brazil.

Department X-ray Microscopy, Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Albert-Einstein-Str. 15, 12489 Berlin, Germany.

出版信息

Nanomaterials (Basel). 2023 Mar 28;13(7):1202. doi: 10.3390/nano13071202.

DOI:10.3390/nano13071202
PMID:37049296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10096983/
Abstract

Co-abietate and Cu-abietate complexes were obtained by a low-cost and eco-friendly route. The synthesis process used resin and an aqueous solution of CuSO/CoSO at a mild temperature (80 °C) without organic solvents. The obtained complexes are functional pigments for commercial architectural paints with antipathogenic activity. The pigments were characterized by Fourier-transform infrared spectroscopy (FTIR), mass spectrometry (MS), thermogravimetry (TG), near-edge X-ray absorption fine structure (NEXAFS), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and colorimetric analysis. In addition, the antibacterial efficiency was evaluated using the minimum inhibitory concentration (MIC) test, and the antiviral tests followed an adaptation of the ISO 21702:2019 guideline. Finally, virus inactivation was measured using the RT-PCR protocol using 10% (/) of abietate complex in commercial white paint. The Co-abietate and Cu-abietate showed inactivation of >4 log against SARS-CoV-2 and a MIC value of 4.50 µg·mL against both bacteria () and (). The results suggest that the obtained Co-abietate and Cu-abietate complexes could be applied as pigments in architectural paints for healthcare centers, homes, and public places.

摘要

通过低成本且环保的途径获得了枞酸钴和枞酸铜配合物。合成过程在温和温度（80°C）下使用树脂以及硫酸铜/硫酸钴水溶液，且不使用有机溶剂。所获得的配合物是具有抗病原活性的商业建筑涂料功能性颜料。通过傅里叶变换红外光谱（FTIR）、质谱（MS）、热重分析（TG）、近边X射线吸收精细结构（NEXAFS）、X射线光电子能谱（XPS）、扫描电子显微镜（SEM）和比色分析对颜料进行了表征。此外，使用最低抑菌浓度（MIC）试验评估了抗菌效率，抗病毒试验遵循了ISO 21702:2019指南的改编版。最后，使用RT-PCR方案测量了商业白色涂料中10%（/）的枞酸配合物的病毒灭活情况。枞酸钴和枞酸铜对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的灭活率>4个对数，对两种细菌（）和（）的MIC值为4.50μg·mL。结果表明，所获得的枞酸钴和枞酸铜配合物可作为颜料应用于医疗中心、家庭和公共场所的建筑涂料中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/7c3360f2424a/nanomaterials-13-01202-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/469f50b3ceeb/nanomaterials-13-01202-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/3b9c81ddbdff/nanomaterials-13-01202-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/b5901fdba7f6/nanomaterials-13-01202-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/261b156df046/nanomaterials-13-01202-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/0177f1f169c8/nanomaterials-13-01202-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/99789068031e/nanomaterials-13-01202-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/73fba4536cec/nanomaterials-13-01202-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/7c3360f2424a/nanomaterials-13-01202-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/469f50b3ceeb/nanomaterials-13-01202-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/3b9c81ddbdff/nanomaterials-13-01202-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/b5901fdba7f6/nanomaterials-13-01202-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/261b156df046/nanomaterials-13-01202-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/0177f1f169c8/nanomaterials-13-01202-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/99789068031e/nanomaterials-13-01202-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/73fba4536cec/nanomaterials-13-01202-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10096983/7c3360f2424a/nanomaterials-13-01202-g008.jpg

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