Katsumi Yuta, Moore Matthew
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
War Related Illness and Injury Study Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States.
Front Behav Neurosci. 2022 Jun 27;16:910180. doi: 10.3389/fnbeh.2022.910180. eCollection 2022.
Subjectively arousing experiences tend to be better remembered than neutral ones. While numerous task-related neuroimaging studies have revealed the neural mechanisms associated with this phenomenon, it remains unclear how variability in the extent to which individuals show superior memory for subjectively arousing stimuli is associated with the functional organization of their brains. Here, we addressed this issue using functional magnetic resonance imaging data collected at rest from a sample drawn from the Cambridge Centre for Ageing and Neuroscience cohort ( = 269, 18-86 years). Specifically, we performed multi-voxel pattern analysis of intrinsic functional connectivity, an unbiased, data-driven approach to examine whole-brain voxel-wise connectivity patterns. This technique allowed us to reveal the most important features from the high-dimensional, whole-brain connectivity structure without hypotheses about the topography and direction of functional connectivity differences. Behaviorally, both item and associative memory accuracy were enhanced for trials with affectively arousing (positive or negative) stimuli than those with neutral ones. Whole-brain multi-voxel pattern analysis of functional connectivity revealed that the affective enhancement of memory was associated with intrinsic connectivity patterns of spatially distributed brain regions belonging to several functional networks in the cerebral cortex. seed-based brain-behavior regression analysis and principal component analysis of the resulting correlation maps showed that these connectivity patterns were in turn primarily characterized by the involvement of heteromodal association and paralimbic (dorsal attention, salience, and default mode) networks of the cerebral cortex as well as select subcortical structures (striatum, thalamus, and cerebellum). Collectively, these findings suggest that the affective enhancement of episodic memory may be characterized as a whole-brain phenomenon, possibly supported by intrinsic functional interactions across several networks and structures in the brain.
主观上引起情绪波动的经历往往比中性经历更容易被记住。虽然众多与任务相关的神经影像学研究已经揭示了与这一现象相关的神经机制，但个体对主观上引起情绪波动的刺激表现出卓越记忆的程度差异如何与他们大脑的功能组织相关联，仍不清楚。在此，我们使用从剑桥衰老与神经科学中心队列（ = 269，18 - 86岁）抽取的样本在静息状态下收集的功能磁共振成像数据来解决这个问题。具体而言，我们对内在功能连接进行了多体素模式分析，这是一种无偏的、数据驱动的方法，用于检查全脑体素水平的连接模式。该技术使我们能够从高维的全脑连接结构中揭示最重要的特征，而无需对功能连接差异的拓扑结构和方向进行假设。在行为上，与中性刺激相比，情感上引起情绪波动（积极或消极）的刺激试验的项目和联想记忆准确性均有所提高。对功能连接的全脑多体素模式分析表明，记忆的情感增强与大脑皮层中几个功能网络的空间分布脑区的内在连接模式相关。基于种子点的脑 - 行为回归分析以及对所得相关图谱的主成分分析表明，这些连接模式反过来主要由大脑皮层的异模态联合和边缘旁（背侧注意、突显和默认模式）网络以及选定的皮层下结构（纹状体、丘脑和小脑）的参与所表征。总体而言，这些发现表明情景记忆的情感增强可能是一种全脑现象，可能由大脑中几个网络和结构之间的内在功能相互作用所支持。
