The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Department of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, China.
J Magn Reson Imaging. 2023 Sep;58(3):720-731. doi: 10.1002/jmri.28599. Epub 2023 Jan 13.
How the functional interactions of the basal ganglia/thalamus with the cerebral cortex and the cerebellum change over the adult lifespan in movie-watching and resting-state is less clear.
To investigate the functional changes in the organization of the human cortical-subcortical functional networks over the adult lifespan using movie-watching and resting-state fMRI data.
Cohort.
Healthy 467 adults (cross-sectional individuals aged 18-88 years) from the Cambridge Centre for Ageing and Neuroscience (www.cam-can.com). FIELD STRENGTH/SEQUENCE: fMRI using a gradient-echo echo-planar imaging (EPI) sequence at 3 T.
Functional connectivities (FCs) of the subcortical subregions (i.e. the basal ganglia and thalamus) with both the cerebral cortex and cerebellum were examined in fMRI data acquired during resting state and movie-watching. And, fluid intelligence scores were also assessed.
Student's t-tests, false discovery rate (FDR) corrected.
As age increased, FCs that mainly within the basal ganglia and thalamus, and between the basal ganglia/thalamus and cortical networks (including the dorsal attention, ventral attention, and limbic networks) were both increased/decreased during movie-watching and resting states. However, FCs showed a state-dependent component with advancing age. During the movie-watching state, the FCs between the basal ganglia/thalamus and cerebellum/frontoparietal control networks were mainly increased with age, and the FCs in the somatomotor network were decreased with age. During the resting state, the FCs between the basal ganglia/thalamus and default mode/visual networks were mainly increased with age, and the FCs in the cerebellum were mainly decreased with age. Moreover, inverse relationships between FCs and fluid intelligence were mainly found in these network regions.
Our study may suggest that changes in cortical-subcortical functional networks across the adult lifespan were both state-dependent and stable traits, and that aging fMRI studies should consider the effects of both physiological characteristics and individual situations.
Stage 3.
基底神经节/丘脑与大脑皮层和小脑在成年期观看电影和休息状态下的功能相互作用如何变化尚不清楚。
使用观看电影和静息状态 fMRI 数据，研究成年期人类皮质下皮质功能网络组织的功能变化。
队列。
来自剑桥衰老与神经科学中心（www.cam-can.com）的 467 名健康成年人（横断面个体年龄 18-88 岁）。
磁场强度/序列：在 3T 时使用梯度回波回波平面成像（EPI）序列进行 fMRI。
在静息状态和观看电影时采集的 fMRI 数据中，检查了皮质下亚区（即基底神经节和丘脑）与大脑皮层和小脑的功能连接（FCs）。此外，还评估了流体智力得分。
学生 t 检验，经 FDR 校正。
随着年龄的增长，在观看电影和静息状态下，基底神经节和丘脑内以及基底神经节/丘脑与皮质网络（包括背侧注意、腹侧注意和边缘网络）之间的 FC 均增加/减少。然而，FC 表现出随年龄增长的状态依赖性成分。在观看电影状态下，基底神经节/丘脑与小脑/额顶控制网络之间的 FC 主要随年龄增加而增加，而躯体运动网络中的 FC 随年龄增加而减少。在静息状态下，基底神经节/丘脑与默认模式/视觉网络之间的 FC 主要随年龄增加而增加，而小脑的 FC 主要随年龄增加而减少。此外，FC 与流体智力之间的负相关关系主要存在于这些网络区域。
我们的研究可能表明，成年期皮质下皮质功能网络的变化既具有状态依赖性又具有稳定特征，并且衰老 fMRI 研究应考虑生理特征和个体情况的影响。
第 3 阶段。
