Khan Fabiha Zaheen, Mostaid Md Shaki, Apu Mohd Nazmul Hasan
Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh.
Heliyon. 2022 Jul 5;8(7):e09874. doi: 10.1016/j.heliyon.2022.e09874. eCollection 2022 Jul.
Alzheimer's disease (AD) is a neurodegenerative disease with rapid progression. Black cumin () is a nutraceutical that has been investigated as a prophylactic and therapeutic agent for this disease due to its ability to prevent or retard the progression of neurodegeneration. Thymoquinone (TQ) is the main bioactive compound isolated from the seeds of black cumin. Several reports have shown that it has promising potential in the prevention and treatment of AD due to its significant antioxidative, anti-inflammatory, and antiapoptotic properties along with several other mechanisms that target the altered signaling pathways due to the disease pathogenesis. In addition, it shows anticholinesterase activity and prevents α-synuclein induced synaptic damage. The aim of this review is to summarize the potential aspects and mechanisms by which TQ imparts its action in AD.
阿尔茨海默病（AD）是一种进展迅速的神经退行性疾病。黑孜然是一种营养保健品，因其具有预防或延缓神经退行性变进展的能力，已被研究作为该疾病的预防和治疗药物。百里醌（TQ）是从黑孜然种子中分离出的主要生物活性化合物。多项报告表明，由于其具有显著的抗氧化、抗炎和抗凋亡特性，以及针对疾病发病机制导致的信号通路改变的其他几种机制，它在AD的预防和治疗方面具有广阔的潜力。此外，它还表现出抗胆碱酯酶活性，并能预防α-突触核蛋白诱导的突触损伤。本综述的目的是总结TQ在AD中发挥作用的潜在方面和机制。
