BAIBA参与肥胖大鼠低氧训练诱导的白色脂肪组织褐变。
BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats.
作者信息
Feng Junpeng, Wang Xuebing, Lu Yingli, Yu Chang, Wang Xinyan, Feng Lianshi
机构信息
Exercise Biology Research Center, China Institute of Sport Science, Beijing, China.
School of Sport Science, Beijing Sport University, Beijing, China.
出版信息
Front Physiol. 2022 Jun 23;13:882151. doi: 10.3389/fphys.2022.882151. eCollection 2022.
In recent years, obesity has become an important risk factor for human health; how to effectively prevent and reduce the occurrence of obesity is a hot research topic in recent years. Hypoxic training effectively improves abnormalities of lipid metabolism caused by obesity. The current study explored the effects of hypoxic training on BAIBA secretion and white fat browning in inguinal fat in obese rats. Analyses were performed by HPLC/MS/MS-MS/MS, RT-q PCR and western blot methods. The findings showed that 4 weeks of hypoxic training reduced body weight, Lee's index, and regulated blood lipid profile in obese rats. Hypoxic training up-regulated BAIBA concentration in gastrocnemius muscle and circulation in obese rats. Hypoxic training significantly upregulated expression of PPARα and UCP-1 in inguinal fat of obese rats and increased white fat browning. The findings showed that BAIBA may involve in improveing blood lipid profile and white fat browning by modulating PPARα and UCP-1 expression.
近年来，肥胖已成为影响人类健康的重要风险因素；如何有效预防和减少肥胖的发生是近年来的研究热点。低氧训练可有效改善肥胖所致的脂质代谢异常。本研究探讨了低氧训练对肥胖大鼠腹股沟脂肪中BAIBA分泌及白色脂肪棕色化的影响。采用高效液相色谱/串联质谱法、逆转录-定量聚合酶链反应和蛋白质免疫印迹法进行分析。结果显示，4周的低氧训练可降低肥胖大鼠的体重、李氏指数，并调节血脂水平。低氧训练上调了肥胖大鼠腓肠肌和循环中的BAIBA浓度。低氧训练显著上调了肥胖大鼠腹股沟脂肪中PPARα和UCP-1的表达，并增加了白色脂肪棕色化。结果表明，BAIBA可能通过调节PPARα和UCP-1的表达参与改善血脂水平和白色脂肪棕色化。
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