Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Shanghai, China.
Ottawa-Shanghai Joint School of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Immunol. 2022 Jun 27;13:895636. doi: 10.3389/fimmu.2022.895636. eCollection 2022.
Intestinal immunity and homeostasis are maintained through the regulation of cytokine trafficking, microbiota, necrosis and apoptosis. Intestinal immunity and homeostasis participate in host defenses and inflammatory responses locally or systemically through the gut-organ axis. NF-κB functions as a crucial transcription factor mediating the expression of proteins related to the immune responses. The activation of NF-κB involves two major pathways: canonical and non-canonical. The canonical pathway has been extensively studied and reviewed. Here, we present the current knowledge of NIK, a pivotal mediator of the non-canonical NF-κB pathway and its role in intestinal immunity and homeostasis. This review also discusses the novel role of NIK signaling in the pathogenesis and treatment of inflammatory bowel disease.
肠道免疫和稳态通过细胞因子运输、微生物群、坏死和凋亡的调节来维持。肠道免疫和稳态通过肠道-器官轴局部或全身参与宿主防御和炎症反应。NF-κB 作为一种关键的转录因子，介导与免疫反应相关的蛋白质的表达。NF-κB 的激活涉及两条主要途径：经典途径和非经典途径。经典途径已得到广泛研究和综述。在这里，我们介绍了非经典 NF-κB 途径的关键介质 NIK 的最新知识及其在肠道免疫和稳态中的作用。本文还讨论了 NIK 信号在炎症性肠病发病机制和治疗中的新作用。
