Suzuki Takuya
Department of Biofunctional Science and Technology, Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Japan.
Program of Food and AgriLife Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Anim Sci J. 2020 Jan-Dec;91(1):e13357. doi: 10.1111/asj.13357.
Tight junctions (TJs) play an important role in intestinal barrier function. TJs in intestinal epithelial cells are composed of different junctional molecules, such as claudin and occludin, and regulate the paracellular permeability of water, ions, and macromolecules in adjacent cells. One of the most important roles of the TJ structure is to provide a physical barrier to luminal inflammatory molecules. Impaired integrity and structure of the TJ barrier result in a forcible activation of immune cells and chronic inflammation in different tissues. According to recent studies, the intestinal TJ barrier could be regulated, as a potential target, by dietary factors to prevent and reduce different inflammatory disorders, although the precise mechanisms underlying the dietary regulation remain unclear. This review summarizes currently available information on the regulation of the intestinal TJ barrier by food components.
紧密连接（TJs）在肠道屏障功能中发挥着重要作用。肠道上皮细胞中的紧密连接由不同的连接分子组成，如闭合蛋白和封闭蛋白，并调节相邻细胞间水、离子和大分子的细胞旁通透性。紧密连接结构最重要的作用之一是为腔内炎症分子提供物理屏障。紧密连接屏障的完整性和结构受损会导致免疫细胞的强力激活和不同组织的慢性炎症。根据最近的研究，肠道紧密连接屏障作为一个潜在靶点，可通过饮食因素进行调节，以预防和减少不同的炎症性疾病，尽管饮食调节的具体机制仍不清楚。本综述总结了目前关于食物成分对肠道紧密连接屏障调节作用的现有信息。
