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啤酒和无酒精啤酒消费对肠道微生物群的影响：一项随机、双盲、对照试验。

Impact of Beer and Nonalcoholic Beer Consumption on the Gut Microbiota: A Randomized, Double-Blind, Controlled Trial.

机构信息

Nutrição e Metabolismo, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.

CINTESIS-Center for Health Technology Services Research, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.

出版信息

J Agric Food Chem. 2022 Oct 19;70(41):13062-13070. doi: 10.1021/acs.jafc.2c00587. Epub 2022 Jun 15.

DOI:10.1021/acs.jafc.2c00587
PMID:35834180
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9776556/
Abstract

Gut microbiota modulation might constitute a mechanism mediating the effects of beer on health. In this randomized, double-blinded, two-arm parallel trial, 22 healthy men were recruited to drink 330 mL of nonalcoholic beer (0.0% v/v) or alcoholic beer (5.2% v/v) daily during a 4-week follow-up period. Blood and faecal samples were collected before and after the intervention period. Gut microbiota was analyzed by 16S rRNA gene sequencing. Drinking nonalcoholic or alcoholic beer daily for 4 weeks did not increase body weight and body fat mass and did not changed significantly serum cardiometabolic biomarkers. Nonalcoholic and alcoholic beer increased gut microbiota diversity which has been associated with positive health outcomes and tended to increase faecal alkaline phosphatase activity, a marker of intestinal barrier function. These results suggest the effects of beer on gut microbiota modulation are independent of alcohol and may be mediated by beer polyphenols.

摘要

肠道微生物群调节可能是介导啤酒对健康影响的机制之一。在这项随机、双盲、双臂平行试验中，招募了 22 名健康男性，在为期 4 周的随访期间，每天饮用 330 毫升无酒精啤酒（0.0%v/v）或酒精啤酒（5.2%v/v）。干预前后采集了血液和粪便样本。通过 16S rRNA 基因测序分析肠道微生物群。连续 4 周每天饮用无酒精或酒精啤酒不会增加体重和体脂肪量，也不会显著改变血清心血管代谢生物标志物。无酒精和酒精啤酒增加了肠道微生物群的多样性，这与健康结果呈正相关，并倾向于增加粪便碱性磷酸酶活性，这是肠道屏障功能的标志物。这些结果表明，啤酒对肠道微生物群调节的影响与酒精无关，可能是由啤酒多酚介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/192e7e20bdd4/jf2c00587_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/f90ec472fdde/jf2c00587_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/20546504e491/jf2c00587_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/c50ecfad5cfb/jf2c00587_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/f8db77cf8a55/jf2c00587_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/0c698bac2254/jf2c00587_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/192e7e20bdd4/jf2c00587_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/f90ec472fdde/jf2c00587_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/20546504e491/jf2c00587_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/c50ecfad5cfb/jf2c00587_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/f8db77cf8a55/jf2c00587_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/0c698bac2254/jf2c00587_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9776556/192e7e20bdd4/jf2c00587_0006.jpg

相似文献

[1]
Impact of Beer and Nonalcoholic Beer Consumption on the Gut Microbiota: A Randomized, Double-Blind, Controlled Trial.

J Agric Food Chem. 2022-10-19

[2]
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[3]
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[4]
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[5]
[Benefits of the beer polyphenols on the gut microbiota].

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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Effects of moderate beer consumption on immunity and the gut microbiome in immunosuppressed mice.

Biosci Microbiota Food Health. 2025

[2]
Physiological Mechanisms by Which the Functional Ingredients in Beer Impact Human Health.

Molecules. 2024-6-29

[3]
Gut Microbiome and Lipidome Signatures in Irritable Bowel Syndrome Patients from a Low-Income, Food-Desert Area: A Pilot Study.

Microorganisms. 2023-10-6

[4]
Oh my gut! Is the microbial origin of neurodegenerative diseases real?

Infect Immun. 2023-10-17

[5]
The effects of moderate alcohol consumption on non-alcoholic fatty liver disease.

Clin Mol Hepatol. 2023-2

本文引用的文献

[1]
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients.

Front Microbiol. 2021-7-19

[2]
Influence of Human Milk on Very Preterms' Gut Microbiota and Alkaline Phosphatase Activity.

Nutrients. 2021-5-6

[3]
A Pilot Study on the Metabolic Impact of Mediterranean Diet in Type 2 Diabetes: Is Gut Microbiota the Key?

Nutrients. 2021-4-8

[4]
Intestinal Barrier Dysfunction, LPS Translocation, and Disease Development.

J Endocr Soc. 2020-2-20

[5]
A New Perspective on the Health Benefits of Moderate Beer Consumption: Involvement of the Gut Microbiota.

Metabolites. 2019-11-9

[6]
Influence of moderate beer consumption on human gut microbiota and its impact on fasting glucose and β-cell function.

Alcohol. 2020-6

[7]
Recent advances in intestinal alkaline phosphatase, inflammation, and nutrition.

Nutr Rev. 2019-10-1

[8]
Modeling of α-acids and xanthohumol extraction in dry-hopped beers.

Food Chem. 2018-11-10

[9]
Effects of moderate beer consumption on health.

Nutr Hosp. 2018-9-7

[10]
Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Lancet. 2018-8-23

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