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人乳对极早产儿肠道微生物群和碱性磷酸酶活性的影响。

Influence of Human Milk on Very Preterms' Gut Microbiota and Alkaline Phosphatase Activity.

机构信息

Faculdade de Ciências Médicas|NOVA Medical School, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.

CHRC-Comprehensive Health Research Centre, CEDOC-Chronic Diseases Research Center, Faculdade de Ciências Médicas|NOVA Medical School, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.

出版信息

Nutrients. 2021 May 6;13(5):1564. doi: 10.3390/nu13051564.

DOI:10.3390/nu13051564
PMID:34066473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8148101/
Abstract

The FEEDMI Study (NCT03663556) evaluated the influence of infant feeding (mother's own milk (MOM), donor human milk (DHM) and formula) on the fecal microbiota composition and alkaline phosphatase (ALP) activity in extremely and very preterm infants (≤32 gestational weeks). In this observational study, preterm infants were recruited within the first 24 h after birth. Meconium and fecal samples were collected at four time points (between the 2nd and the 26th postnatal days. Fecal microbiota was analyzed by RT-PCR and by 16S rRNA sequencing. Fecal ALP activity, a proposed specific biomarker of necrotizing enterocolitis (NEC), was evaluated by spectrophotometry at the 26th postnatal day. A total of 389 fecal samples were analyzed from 117 very preterm neonates. Human milk was positively associated with beneficial bacteria, such as , , and , as well as bacterial richness. Neonates fed with human milk during the first week of life had increased content and fecal ALP activity on the 26th postnatal day. These findings point out the importance of MOM and DHM in the establishment of fecal microbiota on neonates prematurely delivered. Moreover, these results suggest an ALP pathway by which human milk may protect against NEC.

摘要

FEEDMI 研究（NCT03663556）评估了婴儿喂养方式（母亲的自有奶（MOM）、捐献人乳（DHM）和配方奶）对极低和极早产儿（≤32 孕周）粪便微生物组成和碱性磷酸酶（ALP）活性的影响。在这项观察性研究中，早产儿在出生后 24 小时内被招募。胎粪和粪便样本在四个时间点（第 2 至第 26 天）采集。通过 RT-PCR 和 16S rRNA 测序分析粪便微生物群。粪便 ALP 活性是坏死性小肠结肠炎（NEC）的一种拟议特异性生物标志物，在第 26 天通过分光光度法进行评估。从 117 名极早产儿中分析了 389 份粪便样本。人乳与有益细菌呈正相关，如 、 、 和 ，以及细菌丰富度。在生命的第一周内用人乳喂养的新生儿在第 26 天的粪便中 含量和 ALP 活性增加。这些发现指出了 MOM 和 DHM 在早产儿粪便微生物群建立中的重要性。此外，这些结果提示了人乳可能通过 ALP 途径预防 NEC 的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5a/8148101/e414be0e094f/nutrients-13-01564-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5a/8148101/b12b7f876ad3/nutrients-13-01564-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5a/8148101/8db7f8884680/nutrients-13-01564-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5a/8148101/024611a71851/nutrients-13-01564-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5a/8148101/3beabc921fa9/nutrients-13-01564-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5a/8148101/e414be0e094f/nutrients-13-01564-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5a/8148101/b12b7f876ad3/nutrients-13-01564-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5a/8148101/8db7f8884680/nutrients-13-01564-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5a/8148101/024611a71851/nutrients-13-01564-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5a/8148101/3beabc921fa9/nutrients-13-01564-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5a/8148101/e414be0e094f/nutrients-13-01564-g005.jpg

相似文献

[1]
Influence of Human Milk on Very Preterms' Gut Microbiota and Alkaline Phosphatase Activity.

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[2]
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[3]
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[4]
Preterm Gut Microbiome Depending on Feeding Type: Significance of Donor Human Milk.

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[5]
Independent of Birth Mode or Gestational Age, Very-Low-Birth-Weight Infants Fed Their Mothers' Milk Rapidly Develop Personalized Microbiotas Low in Bifidobacterium.

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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Impact of mother's own milk donor human milk on gut microbiota colonization in preterm infants: a systematic review.

Microbiome Res Rep. 2024-11-21

[2]
Bovine colostrum prevents formula-induced gut microbiota dysbiosis in preterm pigs.

Pediatr Res. 2025-2

[3]
Necrotizing enterocolitis: a potential protective role for intestinal alkaline phosphatase as lipopolysaccharide detoxifying enzyme.

Front Pediatr. 2024-4-30

[4]
Effects of Physical Activity and Nutrition Education on the Gut Microbiota in Overweight and Obese Children.

Children (Basel). 2023-7-19

[5]
Therapeutic Potential of Gut Microbiota and Its Metabolite Short-Chain Fatty Acids in Neonatal Necrotizing Enterocolitis.

Life (Basel). 2023-2-16

[6]
Impact of Beer and Nonalcoholic Beer Consumption on the Gut Microbiota: A Randomized, Double-Blind, Controlled Trial.

J Agric Food Chem. 2022-10-19

[7]
Metagenomics Approaches to Investigate the Neonatal Gut Microbiome.

Front Pediatr. 2022-6-21

[8]
Protective Effect of Alkaline Phosphatase Supplementation on Infant Health.

Foods. 2022-4-21

[9]
Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function.

Microorganisms. 2022-3-30

本文引用的文献

[1]
Extremely preterm neonates have more in meconium than very preterm neonates - the microbial colonization hypothesis.

Gut Microbes. 2020-11-9

[2]
Beneficial Effect of Mildly Pasteurized Whey Protein on Intestinal Integrity and Innate Defense in Preterm and Near-Term Piglets.

Nutrients. 2020-4-17

[3]
Gut Mucosal and Fecal Microbiota Profiling Combined to Intestinal Immune System in Neonates Affected by Intestinal Ischemic Injuries.

Front Cell Infect Microbiol. 2020-2-25

[4]
Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides ovatus and Are Modifiable by Gut Microbiota Manipulation.

Cell Host Microbe. 2020-2-18

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Necrotizing Enterocolitis: A Multi-omic Approach and the Role of the Microbiome.

Dig Dis Sci. 2020-3

[6]
Using MicrobiomeAnalyst for comprehensive statistical, functional, and meta-analysis of microbiome data.

Nat Protoc. 2020-1-15

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Early environment and long-term outcomes of preterm infants.

J Neural Transm (Vienna). 2020-1

[8]
Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants.

JAMA Netw Open. 2019-11-1

[9]
Preterm neonatal immunology at the intestinal interface.

Cell Mol Life Sci. 2019-10-1

[10]
FEEDMI: A Study Protocol to Determine the Influence of Infant-Feeding on Very-Preterm-Infant's Gut Microbiota.

Neonatology. 2019-5-27

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