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Fetal hemoglobin enables malaria parasite growth in sickle cells but augments production of transmission stage parasites.胎儿血红蛋白可使疟原虫在镰状细胞中生长,但会增加传播阶段疟原虫的产生。
PLoS One. 2025 Jul 8;20(7):e0325797. doi: 10.1371/journal.pone.0325797. eCollection 2025.

本文引用的文献

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Revisiting the malaria hypothesis: accounting for polygenicity and pleiotropy.重新审视疟疾假说:考虑多基因性和多效性。
Trends Parasitol. 2022 Apr;38(4):290-301. doi: 10.1016/j.pt.2021.12.007. Epub 2022 Jan 19.
2
Common host variation drives malaria parasite fitness in healthy human red cells.常见的宿主变异驱动健康人类红细胞中的疟原虫适应性。
Elife. 2021 Sep 23;10:e69808. doi: 10.7554/eLife.69808.
3
Fetal hemoglobin does not inhibit growth.胎儿血红蛋白不会抑制生长。
Blood Adv. 2019 Jul 23;3(14):2149-2152. doi: 10.1182/bloodadvances.2019000399.
4
Resistance to in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition.镰状细胞特征红细胞对 的抗性是由氧依赖性生长抑制驱动的。
Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7350-7355. doi: 10.1073/pnas.1804388115. Epub 2018 Jun 26.
5
Fetal Hemoglobin Modifies the Disease Manifestation of Severe Malaria in Adult Patients with Sickle Cell Anemia.胎儿血红蛋白改变镰状细胞贫血成年患者严重疟疾的疾病表现。
Mediterr J Hematol Infect Dis. 2016 Nov 1;8(1):e2016055. doi: 10.4084/MJHID.2016.055. eCollection 2016.
6
Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes.氧化损伤可诱导镰状和胎儿红细胞产生疟原虫保护特性。
Nat Commun. 2016 Nov 8;7:13401. doi: 10.1038/ncomms13401.
7
Negative Epistasis between Sickle and Foetal Haemoglobin Suggests a Reduction in Protection against Malaria.镰状血红蛋白与胎儿血红蛋白之间的负上位性表明对疟疾的保护作用降低。
PLoS One. 2015 May 12;10(5):e0125929. doi: 10.1371/journal.pone.0125929. eCollection 2015.
8
In vitro growth of Plasmodium falciparum in neonatal blood.恶性疟原虫在新生儿血液中的体外生长
Malar J. 2014 Nov 18;13:436. doi: 10.1186/1475-2875-13-436.
9
A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria.胎儿血红蛋白和母体免疫 IgG 在婴儿抵抗恶性疟原虫疟疾中的作用。
PLoS One. 2011 Apr 12;6(4):e14798. doi: 10.1371/journal.pone.0014798.
10
[Demonstration of fetal hemoglobin in erythrocytes of a blood smear].[血涂片红细胞中胎儿血红蛋白的显示]
Klin Wochenschr. 1957 Jun 15;35(12):637-8. doi: 10.1007/BF01481043.

Does fetal hemoglobin inhibit the malarial parasite Plasmodium falciparum?

作者信息

Archer Natasha M, Pasvol Geoffrey, Wilson Iain, Duraisingh Manoj T

机构信息

Pediatric Hematology/Oncology Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

出版信息

Am J Hematol. 2022 Sep;97(9):E325-E327. doi: 10.1002/ajh.26661. Epub 2022 Jul 30.

DOI:10.1002/ajh.26661
PMID:35834276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9428829/
Abstract
摘要