Giustiniani S, Robustelli della Cuna F, Marieni M
Int J Cardiol. 1987 May;15(2):247-9. doi: 10.1016/0167-5273(87)90322-6.
This report concerns a patient with ischemic heart disease, who developed hyperplastic gingivitis with verapamil. The gingivitis resolved completely when the drug was discontinued, but recurred when another calcium antagonist, diltiazem, was administered. It is suggested that it is the mechanism of action of calcium antagonists which is responsible for the gingival changes.
本报告涉及一名患有缺血性心脏病的患者，该患者使用维拉帕米后出现了增生性牙龈炎。停用该药后，牙龈炎完全消退，但在使用另一种钙拮抗剂地尔硫䓬时又复发了。提示钙拮抗剂的作用机制是导致牙龈改变的原因。
