Cucchi G, Giustiniani S, Robustelli F
G Ital Cardiol. 1985 May;15(5):556-7.
We observed gingival hyperplasia, similar clinically to the hyperplasia caused by diphenylhydantoin during the last 11 months in two patients treated by verapamil, suffering from angina pectoris pains. In Case I discontinuation of the calcium antagonist resulted in marked regression of the gingival hyperplasia. Evidence points to a strong relationship between the gingival hyperplasia and the administration of verapamil. Further studies are required to confirm definitively the relationship between the administration of verapamil and gingival hyperplasia, its incidence, and the correlation with local factors.
在过去11个月里，我们观察到两名接受维拉帕米治疗的心绞痛患者出现了牙龈增生，临床上与苯妥英引起的增生相似。在病例I中，停用钙拮抗剂后牙龈增生明显消退。有证据表明牙龈增生与维拉帕米的使用之间存在密切关系。需要进一步研究以明确证实维拉帕米的使用与牙龈增生之间的关系、其发生率以及与局部因素的相关性。
