抗生素治疗引发的炎症之火经久不息。

Antibiotic treatment ignites a fire that lasts.

机构信息

Department of Microbiology and Immunology, Loyola University Chicago - Stritch School of Medicine, 2160 S. First Avenue, Maywood, IL 60153, USA.

出版信息

Cell Host Microbe. 2022 Jul 13;30(7):897-899. doi: 10.1016/j.chom.2022.06.001.

DOI:10.1016/j.chom.2022.06.001

PMID:35834957

Abstract

Tissue damage and persistent inflammation are distinctive features of antibiotic-resistant chronic infections. In this issue of Cell Host & Microbe, Tang et al. demonstrate that anti-folate antibiotics trigger the synthesis of a bacterial second messenger, which induces an exuberant immune response and establishes a paradigm for chronic infection.

摘要

组织损伤和持续炎症是抗生素耐药性慢性感染的显著特征。在本期《细胞宿主与微生物》中，Tang 等人证明抗叶酸抗生素会触发细菌第二信使的合成，从而引发过度的免疫反应，并为慢性感染建立了一个范例。