长期使用抗生素后，多米诺骨牌开始倒下。
The dominoes fall after long-term antibiotic exposure.
机构信息
CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Department of Molecular & Biomedical Sciences, University of Maine, Orono, ME, USA; Graduate School of Biomedical Sciences, University of Maine, Orono, ME, USA.
出版信息
Cell Host Microbe. 2022 Jul 13;30(7):903-905. doi: 10.1016/j.chom.2022.06.007.
Abstract
Broad-spectrum antibiotics should prevent disease, right? In this issue of Cell Host & Microbe, Drummond et al. turn logic on its head and show they actually drive more deadly invasive fungal-bacterial systemic co-infection. Prophylactic antibiotics increase susceptibility to these infections by targeting the commensal microbes required for gut-derived IL-17-mediated immunity.
摘要
广谱抗生素应该能预防疾病，对吧？在本期《细胞宿主与微生物》杂志中，Drummond 等人颠覆了这一逻辑，表明它们实际上会导致更致命的侵袭性真菌-细菌全身合并感染。预防性抗生素通过靶向肠道来源的 IL-17 介导免疫所需的共生微生物，增加了对这些感染的易感性。
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