罗伊氏乳杆菌加入肝脏自身免疫领域。
Lactobacillus reuteri joins the liver autoimmune arena.
机构信息
Center for Inflammation Research, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Cell Host Microbe. 2022 Jul 13;30(7):901-903. doi: 10.1016/j.chom.2022.06.004.
Abstract
Type 1 CD8 T cells (Tc1s) have been implicated in liver injury in autoimmune hepatitis (AIH) through mechanisms that have so far been unclear. In this issue of Cell Host & Microbe, Pandey et al. show that the aryl hydrocarbon receptor ligand-producing pathobiont Lactobacillus reuteri induces Tc1-mediated AIH-like pathology in mice with Tet-methylcytosine-dioxygenase-2 deficiency.
摘要
1 型 CD8 T 细胞 (Tc1) 通过目前尚不清楚的机制被认为与自身免疫性肝炎 (AIH) 中的肝损伤有关。在本期《Cell Host & Microbe》杂志上，Pandey 等人表明，芳香烃受体配体产生的条件致病菌罗伊氏乳杆菌在 Tet-甲基胞嘧啶双加氧酶-2 缺陷的小鼠中诱导 Tc1 介导的 AIH 样病理。
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