Rehabilitation Engineering Laboratory, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland; Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Clinical Neuroscience Centre, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Clinical Neuroscience Centre, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Neurobiol Dis. 2022 Oct 1;172:105818. doi: 10.1016/j.nbd.2022.105818. Epub 2022 Jul 11.
Deep brain stimulation (DBS) electrodes provide an unparalleled window to record and investigate neuronal activity right at the core of pathological brain circuits. In Parkinson's disease (PD), basal ganglia beta-oscillatory activity (13-35 Hz) seems to play an outstanding role. Conventional DBS, which globally suppresses beta-activity, does not meet the requirements of a targeted treatment approach given the intricate interplay of physiological and pathological effects of beta-frequencies. Here, we wanted to characterise the local field potential (LFP) in the subthalamic nucleus (STN) in terms of beta-burst prevalence, amplitude and length between movement and rest as well as during self-paced as compared to goal-directed motor control. Our electrophysiological recordings from externalised DBS-electrodes in nine patients with PD showed a marked decrease in beta-burst durations and prevalence during movement as compared to rest as well as shorter and less frequent beta-bursts during cued as compared to self-paced movements. These results underline the importance of beta-burst modulation in movement generation and are in line with the clinical observation that cued motor control is better preserved than self-paced movements. Furthermore, our findings motivate the use of adaptive DBS based on beta-bursts, which selectively trim longer beta-bursts, as it is more suitable and efficient over a range of motor behaviours than conventional DBS.
深部脑刺激 (DBS) 电极提供了无与伦比的窗口，可以在病理大脑回路的核心直接记录和研究神经元活动。在帕金森病 (PD) 中，基底神经节的β 振荡活动（13-35 Hz）似乎起着突出的作用。鉴于β 频率的生理和病理效应的复杂相互作用，全局抑制β 活动的常规 DBS 不符合靶向治疗方法的要求。在这里，我们希望根据运动和休息之间以及自我调节运动与目标导向运动控制期间的β-爆发出现率、振幅和长度来描述丘脑底核 (STN) 的局部场电位 (LFP)。我们对九名 PD 患者的外部化 DBS 电极进行的电生理记录显示，与休息相比，运动期间β-爆发的持续时间和出现率明显减少，与自我调节运动相比，β-爆发的持续时间更短，出现频率更低。这些结果强调了β-爆发调制在运动产生中的重要性，与临床观察一致，即提示运动控制比自我调节运动保存得更好。此外，我们的研究结果促使使用基于β-爆发的自适应 DBS，因为它比传统的 DBS 更适合和高效，可以适用于一系列运动行为。
