成年人脑震荡管理的生存系统综述方案。

Protocol for a living systematic review for the management of concussion in adults.

机构信息

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Ottawa Hospital Rehabilitation Centre, Ottawa Hospital, Ottawa, Ontario, Canada.

出版信息

BMJ Open. 2022 Jul 14;12(7):e061282. doi: 10.1136/bmjopen-2022-061282.

Abstract

INTRODUCTION

Concussion/mild traumatic brain injury (mTBI) often presents initially with disabling symptoms that resolve, but for an unfortunate minority some of these symptoms may become prolonged. Although research into diagnosis and interventions for concussion is increasing, study quality overall remains low. A living systematic review that is updated as evidence becomes available is the ideal research activity to inform a living guideline targeting clinicians and patients. The purpose of this paper is to present the protocol of an ongoing living systematic review for the management of adult concussion that will inform living guidelines building off the Guideline for Concussion/Mild Traumatic Brain Injury and Persistent Symptoms: third Edition.

METHODS AND ANALYSIS

The Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol guidelines were followed in the reporting of this systematic review protocol. We are including English peer-reviewed observational studies, trials, qualitative studies, systematic reviews and clinical practice guidelines related to diagnosis/assessment or treatment of adult concussion. Future searches will be conducted at minimum every 6 months using the following databases: MEDLINE ALL, EMBASE, Cochrane, PsycInfo and CINAHL. The data are managed in the Covidence website. Screening, data extraction and risk-of-bias assessments are being done through multiple raters working independently. Multiple validated tools are being used to assess risk of bias, and the tool applied matches the document or study design (eg, Downs and Black Scale for healthcare interventions). Many concussion experts in various clinical disciplines from across North America have volunteered to examine the evidence in order to make recommendations for the living guidelines.

ETHICS AND DISSEMINATION

No ethical approval is necessary because primary data are not collected. The results will be disseminated through peer-reviewed publications and on the living guidelines website once built.

PROSPERO REGISTRATION NUMBER

CRD42022301786.

摘要

简介

脑震荡/轻度创伤性脑损伤(mTBI)常表现为初始症状明显,且这些症状会缓解,但不幸的是,少数患者的一些症状可能会持续存在。尽管针对脑震荡的诊断和干预措施的研究正在增加,但总体研究质量仍然较低。一个不断更新的实时系统评价,即随着证据的出现而更新,是为针对临床医生和患者的实时指南提供信息的理想研究活动。本文旨在介绍一项针对成人脑震荡管理的实时系统评价的方案,该方案将为基于《脑震荡/轻度创伤性脑损伤和持续性症状指南:第三版》的实时指南提供信息。

方法和分析

本系统评价方案的报告遵循了系统评价和荟萃分析报告的首选条目(PRISMA)指南。我们纳入了与成人脑震荡的诊断/评估或治疗相关的英语同行评议观察性研究、试验、定性研究、系统评价和临床实践指南。未来的搜索将至少每 6 个月使用以下数据库进行:MEDLINE ALL、EMBASE、Cochrane、PsycInfo 和 CINAHL。数据在 Covidence 网站上进行管理。筛选、数据提取和偏倚风险评估由多个独立工作的评估员进行。正在使用多个经过验证的工具来评估偏倚风险,并且所使用的工具与文档或研究设计相匹配(例如,针对医疗保健干预措施的 Downs 和 Black 量表)。来自北美的多个不同临床学科的许多脑震荡专家自愿检查证据,以便为实时指南提出建议。

伦理和传播

由于不收集原始数据,因此不需要伦理批准。结果将通过同行评议出版物和实时指南网站传播,一旦建立。

PROSPERO 注册号:CRD42022301786。

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