Public Health Department, Quality Officer, GAMBY Teaching General Hospital, Bahir Dar, Ethiopia.
Public Health Department, Research and Development Head, GAMBY Medical and Business College, Bahir Dar, Ethiopia.
Sci Rep. 2022 Jul 14;12(1):12000. doi: 10.1038/s41598-022-16132-3.
Ceftriaxone is a broad spectrum of widely used antibiotics as it is highly effective against Gram-negative and Gram-positive isolates. Research on Ceftriaxone resistance helps to know its current status. Hence, we aimed to identify the prevalence of Ceftriaxone resistance on bacteria isolated from clinical specimens among patients at GAMBY Teaching General Hospital Bahir Dar, Ethiopia. Hospital-based retrospective cross-sectional study was conducted at GAMBY teaching General Hospital from November 01, 2015, to December 30, 2020, on 402 clinical specimens. Ceftriaxone susceptibility tests were carried out using the Kirby-Bauer disc diffusion method. Descriptive statistics and chi-square tests were applied for the analysis. Escherichia coli 114 (28.4%), S. aureus 90 (22.4%), S. saprophyticus 42 (10.4%), and Klebsiella spp 42 (10.4%) were the predominant identified bacteria. The overall resistance of ceftriaxone was 230 (57.2%). Sex and type of the clinical specimens had significantly associated with its resistance whereas age was not associated with ceftriaxone resistance. Ceftriaxone resistance has been steadily increasing. Ceftriaxone resistance was high. Sex and type of the clinical specimens had significantly associated with its resistance. Prevention mechanisms to ceftriaxone resistance should be strictly implemented. The right drugs should be selected based on susceptibility patterns.
头孢曲松是一种广谱抗生素，广泛应用于临床，对革兰氏阴性菌和革兰氏阳性菌具有高度的抗菌活性。对头孢曲松耐药性的研究有助于了解其现状。因此，我们旨在确定埃塞俄比亚巴赫达尔甘比教学综合医院患者临床标本中分离出的细菌对头孢曲松的耐药率。本研究为 2015 年 11 月 1 日至 2020 年 12 月 30 日在甘比教学综合医院进行的一项基于医院的回顾性横断面研究，共检测了 402 份临床标本。头孢曲松药敏试验采用 Kirby-Bauer 纸片扩散法进行。采用描述性统计和卡方检验进行分析。主要鉴定出的细菌有大肠埃希菌 114 株（28.4%）、金黄色葡萄球菌 90 株（22.4%）、腐生葡萄球菌 42 株（10.4%）和克雷伯菌属 42 株（10.4%）。头孢曲松的总耐药率为 230 株（57.2%）。性别和临床标本类型与耐药性显著相关，而年龄与头孢曲松耐药性无关。头孢曲松耐药性呈持续上升趋势。头孢曲松耐药率较高。性别和临床标本类型与耐药性显著相关。应严格执行预防头孢曲松耐药的机制。应根据药敏试验结果选择合适的药物。
