Max Planck Institute for Dynamics and Self-Organization, Göttingen, 37077, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Göttingen, 37075, Germany.
Sci Rep. 2022 Jul 14;12(1):12043. doi: 10.1038/s41598-022-16068-8.
The conventional termination technique of life threatening cardiac arrhythmia like ventricular fibrillation is the application of a high-energy electrical defibrillation shock, coming along with severe side-effects. In order to improve the current treatment reducing these side-effects, the application of pulse sequences of lower energy instead of a single high-energy pulse are promising candidates. In this study, we show that in numerical simulations the dose-response function of pulse sequences applied to two-dimensional spiral wave chaos is not necessarily monotonously increasing, but exhibits a non-trivial frequency dependence. This insight into crucial phenomena appearing during termination attempts provides a deeper understanding of the governing termination mechanisms in general, and therefore may open up the path towards an efficient termination of cardiac arrhythmia in the future.
传统的危及生命的心律失常（如心室颤动）的终止技术是应用高能电除颤电击，同时伴随着严重的副作用。为了改善当前的治疗方法，减少这些副作用，应用低能量的脉冲序列而不是单个高能脉冲是很有前途的选择。在这项研究中，我们表明，在数值模拟中，应用于二维螺旋波混沌的脉冲序列的剂量-反应函数不一定是单调递增的，而是表现出非平凡的频率依赖性。这种对终止尝试过程中出现的关键现象的深入了解，为一般的终止机制提供了更深入的理解，因此可能为未来有效地终止心律失常开辟道路。
