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[植入式自动心脏复律除颤器]

[The implantable automatic cardioverter-defibrillator].

作者信息

Klein H, Tröster J, Trappe H J, Becht I, Siclari F

机构信息

Department Innere Medizin und Dermatologie, Medizinische Hochschule Hannover.

出版信息

Herz. 1990 Apr;15(2):111-25.

PMID:2188891
Abstract

In addition to medical treatment for ventricular tachyarrhythmias which has not proven to be sufficient, nonmedical modes of treatment are available such as electrophysiologically-guided surgical measures and catheter ablation, both of which are restricted to only a relatively small patient population and require further technical refinement. In 1980, Mirowski introduced the automatic implantable defibrillator and, to date, world-wide, this device has been implanted in 8000 patients. CHARACTERISTICS AND IMPLANTATION OF THE AUTOMATIC IMPLANTABLE CARDIOVERTER/DEFIBRILLATOR (AICD): The AICD continuously monitors the electrical activity of the heart, recognizes the onset of threatening ventricular tachycardias and terminates these according to the respectively programmed mode by delivering direct current shocks or stimuli. The currently used defibrillators consist of an impulse generator with lithium batteries and an electrode system. The batteries can charge a capacitor with about 700 volts in five to eight seconds which produces a current with an energy up to 30 Joules on discharge. The current is delivered either by two plate electrodes on the right and left ventricles or a plate electrode on the left ventricle and a spiral electrode inserted in the superior vena cava. The electrodes also serve the purpose of tachycardia detection by means of an electrical signal, the probability density function (PDF), that is, a significant decrease in the potentials to isoelectric. With this, it is only possible to terminate ventricular fibrillation. Additional electrical detection criteria are obtained and analyzed by two adjacently positioned epicardial screw electrodes or a bipolar endocardial electrode, enable identification of ventricular tachycardia as well. If the tachycardia detection criteria are fulfilled, the capacitor is discharged according to its programmed shock energy. In 1988, programmable defibrillators were introduced. Current defibrillator treatment also incorporates the possibility for antitachycardia stimulation. Attempts to use, instead of the monophase, square-wave impulse, a biphasic defibrillation impulse, to achieve a sequential impulse and to make use of the bidirectional impulse extension have rendered improved reliability for tachycardia termination and energy savings. After median sternotomy, the plate electrodes are usually sutured to the epicardium and the spiral electrode for the bipolar ECG is positioned at the anterior aspect of the right ventricle. The generator is implanted on the left side para-umbilically in subcutaneous or subfascial tissue. With the subxyphoid approach to avoid sternotomy, the plate electrode is sutured extrapericardially over the left ventricle and the spiral electrode is positioned at the epicardium. Alternatively, for those in whom prior cardiac surgery has been carried out, a lateral thoracotomy can be used. The defibrillation threshold, that is the lowest possible energy for defibrillation of ventricular fibrillation or ventricular tachycardia, should be determined intraoperatively after stimulation of the arrhythmia. The energy required for termination of a stable ventricular tachycardia is usually less than that for termination of ventricular fibrillation and can be determined postoperatively. A margin of security should be taken into consideration which, for defibrillation thresholds of up to 10 Joules, is about twice the amount of the defibrillation threshold itself.(ABSTRACT TRUNCATED AT 400 WORDS)

摘要

除了对室性快速心律失常的药物治疗被证明并不充分外,还存在非药物治疗方式,如电生理引导下的外科手术措施和导管消融术,但这两种方法都仅适用于相对较少的患者群体,并且需要进一步的技术改进。1980年,米罗夫斯基发明了自动植入式除颤器,到目前为止,全球已有8000名患者植入了该设备。自动植入式心脏复律除颤器(AICD)的特点及植入:AICD持续监测心脏的电活动,识别威胁生命的室性快速心律失常的发作,并根据预先设定的模式,通过输送直流电电击或刺激来终止这些心律失常。目前使用的除颤器由带锂电池的脉冲发生器和电极系统组成。电池可在5至8秒内将一个电容器充电至约700伏,放电时产生能量高达30焦耳的电流。电流通过左右心室的两个平板电极或左心室的一个平板电极以及插入上腔静脉的螺旋电极输送。电极还通过电信号,即概率密度函数(PDF),也就是电位显著下降至等电位来实现心动过速检测。通过这种方式,仅能终止心室颤动。另外的电检测标准通过两个相邻放置的心外膜螺旋电极或一个双极心内膜电极获得并分析,也能够识别室性心动过速。如果满足心动过速检测标准,电容器根据其编程的电击能量放电。1988年,引入了可编程除颤器。目前的除颤器治疗还包括抗心动过速刺激的可能性。尝试使用双相除颤脉冲而非单相方波脉冲,以实现序列脉冲并利用双向脉冲扩展,从而提高了心动过速终止的可靠性并节省了能量。在正中胸骨切开术后,平板电极通常缝合至心外膜,用于双极心电图的螺旋电极置于右心室前侧。发生器植入左侧脐旁的皮下或筋膜下组织。采用剑突下途径以避免胸骨切开术时,平板电极在心包外缝合于左心室上方,螺旋电极置于心外膜。或者,对于之前已进行心脏手术的患者,可采用侧胸切开术。除颤阈值,即心室颤动或室性心动过速除颤所需的最低能量,应在术中诱发心律失常后确定。终止稳定室性心动过速所需的能量通常低于终止心室颤动所需的能量,且可在术后确定。应考虑安全余量,对于高达10焦耳的除颤阈值,安全余量约为除颤阈值本身的两倍。(摘要截选至400字)

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