Bains Jaskaran, Carver Scott, Hua Susan
Therapeutic Targeting Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
School of Natural Sciences, University of Tasmania, Hobart, TAS, Australia.
Front Vet Sci. 2022 Jun 28;9:944578. doi: 10.3389/fvets.2022.944578. eCollection 2022.
is an invasive parasitic mite that negatively impacts wombats, causing sarcoptic mange disease, characterized by alopecia, intense pruritus, hyperkeratosis, and eventual mortality. Evidence suggests that wombats may be unable to recovery from infection without the assistance of treatments. Transdermal drug delivery is considered the most ideal route of administration for treatment in free-ranging wombats, as it is non-invasive and avoids the need to capture affected individuals. Although there are effective antiparasitic drugs available, an essential challenge is adequate administration of drugs and sufficient drug retention and absorption when delivered. This review will describe the implications of sarcoptic mange on the physiology of wombats as well as discuss the most widely used antiparasitic drugs to treat (ivermectin, moxidectin, and fluralaner). The prospects for improved absorption of these drugs will be addressed in the context of pathophysiological and pharmaceutical considerations influencing transdermal drug delivery in wombats with sarcoptic mange.
是一种侵袭性寄生螨，对袋熊产生负面影响，引发疥螨病，其特征为脱毛、剧烈瘙痒、角化过度，最终导致死亡。有证据表明，袋熊若没有治疗的帮助可能无法从感染中恢复。经皮给药被认为是自由放养袋熊治疗的最理想给药途径，因为它是非侵入性的，且无需捕获受影响的个体。尽管有有效的抗寄生虫药物，但一个关键挑战是药物的充分给药以及给药时足够的药物保留和吸收。本综述将描述疥螨病对袋熊生理的影响，并讨论治疗中最广泛使用的抗寄生虫药物（伊维菌素、莫西菌素和氟雷拉纳）。将在影响患有疥螨病袋熊经皮给药的病理生理和药学考虑背景下探讨这些药物改善吸收的前景。
