Shen Huili, Chen Yijie, Li Xiaohui, Yan Jing, Zhao Junjie, Kong Demin, Shi Yanxia, Li Zhihui, Wang Jihong, Shao Na, Wang Zhenghui
Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Otolaryngology-Head and Neck Surgery, The Fourth People's Hospital of Shaanxi Province, Xi'an, China.
Evid Based Complement Alternat Med. 2022 Jul 5;2022:8266321. doi: 10.1155/2022/8266321. eCollection 2022.
This study was designed to explore the relationship between (Hp) infection and reflux laryngopharyngitis (RLP) and to evaluate the outcome of anti-Hp therapy in improving RLP symptoms.
A total of 410 patients with RLP were enrolled and tested for Hp infection. The association of Hp infection with reflux symptom index (RSI) and reflux finding score (RFS) was determined. Hp-positive patients received either a proton pump inhibitor (PPI) omeprazole alone (control group) or a combination regimen (experimental group) consisting of omeprazole, mosapride citrate, amoxicillin, and clarithromycin. Therapeutic outcomes were compared 4 weeks later.
Of the 410 participants, 290 were Hp-positive and 120 Hp-negative. Both RSI and RFS were significantly higher in Hp-positive patients than in Hp-negative patients. Hp infection status was positively correlated with RSI ( < 0.05) and RFS ( < 0.05). The overall response rate was higher in the experimental group than in the control group. Both the groups had a significant reduction in RSI and RFS after therapy, with a greater improvement in the experimental group ( < 0.05).
Our findings establish a link between Hp infection and RLP. Anti-Hp therapy improves RSI and RFS in RLP patients. Therefore, Hp eradication drugs may be added to the PPI-based regimen in the treatment of RLP.
本研究旨在探讨幽门螺杆菌（Hp）感染与反流性喉咽炎（RLP）之间的关系，并评估抗Hp治疗改善RLP症状的效果。
共纳入410例RLP患者，检测Hp感染情况。确定Hp感染与反流症状指数（RSI）和反流发现评分（RFS）之间的关联。Hp阳性患者分别接受单独使用质子泵抑制剂（PPI）奥美拉唑（对照组）或由奥美拉唑、枸橼酸莫沙必利、阿莫西林和克拉霉素组成的联合治疗方案（试验组）。4周后比较治疗效果。
410名参与者中，290名Hp阳性，120名Hp阴性。Hp阳性患者的RSI和RFS均显著高于Hp阴性患者。Hp感染状态与RSI（<0.05）和RFS（<0.05）呈正相关。试验组的总体缓解率高于对照组。两组治疗后RSI和RFS均显著降低，试验组改善更明显（<0.05）。
我们的研究结果证实了Hp感染与RLP之间的联系。抗Hp治疗可改善RLP患者的RSI和RFS。因此，在RLP治疗中，基于PPI的治疗方案中可加用根除Hp的药物。
