Sârbu Fabiola, Oprea Violeta Diana, Tatu Alin Laurențiu, Drima Eduard Polea, Ștefănescu Cristina, Nechita Aurel, Onose Gelu, Romila Aurelia
Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800216 Galati, Romania.
Clinical Psychiatry Department, 'Elisabeta Doamna' Psychiatric Hospital of Galati, 800179 Galati, Romania.
Exp Ther Med. 2022 Jun 7;24(2):497. doi: 10.3892/etm.2022.11424. eCollection 2022 Aug.
The complex manifestations of COVID-19 include psychiatric symptoms, having multifaceted profiles with varying severity during the acute phase and further during the recovery period. Limited data exist which have analyzed whether there are any age-related differences. A study lot of 89 COVID-19 patients with mild-to-moderate SARS-CoV-2 infection requiring hospitalization for mental issues provided comparative data from two age groups below and above 60 years. The majority of patients had new onset of a mental issue during COVID-19, 24.7% of the total lot being diagnosed with depressive disorder. The senior patient set had a significantly higher prevalence of sleep disorder vs. the younger study group (53.3 vs. 28.8%), depression (33.3 vs. 10.2%) and cognitive impairment (26.7 vs. 8.5%), while patients <60 years of age had a higher prevalence of hallucinations, delirium and bizarre behavior. Psychiatric manifestations are an important part of the symptomatology of COVID-19, sometimes requiring hospitalization. Age-related neuropsychiatric substrate could explain some of these differences between the two study subgroups. Further data are needed to complete the acute and long-term distinctive profiles of COVID-19-related mental illness in older and younger patients.
新型冠状病毒肺炎（COVID-19）的复杂表现包括精神症状，在急性期以及恢复期呈现出多方面特征且严重程度各异。分析是否存在年龄相关差异的数据有限。一项针对89例因精神问题需住院治疗的轻度至中度严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的COVID-19患者的研究，提供了60岁及以下和60岁以上两个年龄组的对比数据。大多数患者在感染COVID-19期间出现新发精神问题，占总病例数的24.7%被诊断为抑郁症。老年患者组睡眠障碍的患病率显著高于年轻研究组（53.3%对28.8%）、抑郁症（33.3%对10.2%）和认知障碍（26.7%对8.5%），而60岁以下患者幻觉、谵妄和怪异行为的患病率更高。精神症状是COVID-19症状学的重要组成部分，有时需要住院治疗。年龄相关的神经精神基础可以解释这两个研究亚组之间的一些差异。需要更多数据来完善老年和年轻患者中COVID-19相关精神疾病的急性期和长期特征。
