Üçüncü Kefeli Ayşegül, Aksu Beyza
Department of Radiation Oncology, Kocaeli University Hospital, 41000 Kocaeli, Turkey.
Vocational School of Health Services, Kocaeli University Hospital, 41000 Kocaeli, Turkey.
Exp Ther Med. 2022 Jun 15;24(2):516. doi: 10.3892/etm.2022.11443. eCollection 2022 Aug.
The present study described a radiation recall (RR) myositis case following docetaxel chemotherapy in a 26-year-old female with metastatic breast cancer. The left pubis and left femur head and neck were treated with palliative radiotherapy to a dose of 20 Gy in 5 daily fractions. After 2 months, a whole-body positron emission tomography scan revealed new lesions, and systemic treatment was initiated with docetaxel chemotherapy (75 mg/m, every 3 weeks). After the second dose, the patient started to feel pain in her left femur with erythema on her skin on the lumbar and gluteal region, in addition to swelling. On magnetic resonance imaging, edematous changes, increased signal enhancement on T2 and increased contrast uptake of muscles were observed, suggesting myositis on the irradiated field. The present study is the second case report published on the literature on RR myositis following docetaxel treatment, which emphasizes the importance of awareness about this phenomenon when considering differential diagnosis of pain.
本研究描述了一名26岁转移性乳腺癌女性患者在多西他赛化疗后发生的放射性回忆（RR）性肌炎病例。对左侧耻骨、左侧股骨头及颈部进行姑息性放疗，每日1次，每次剂量20 Gy，共5次。2个月后，全身正电子发射断层扫描显示出现新病灶，遂开始使用多西他赛化疗进行全身治疗（75 mg/m²，每3周1次）。第二次给药后，患者开始感到左股骨疼痛，腰部和臀部皮肤出现红斑，伴有肿胀。磁共振成像显示有水肿改变，T2加权像上信号增强，肌肉对比剂摄取增加，提示照射野出现肌炎。本研究是文献中发表的第二例关于多西他赛治疗后RR性肌炎的病例报告，强调了在考虑疼痛鉴别诊断时认识这一现象的重要性。
