Wu Mingzhong, Yan Chaoxian, Zhuang Daijiao, Yan Rulong
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
College of Chemistry and Chemical Engineering, Ankang University, Ankang 725000, P. R. China.
Org Lett. 2022 Jul 29;24(29):5309-5313. doi: 10.1021/acs.orglett.2c01907. Epub 2022 Jul 15.
A general approach for the metal-free synthesis of thiophenes by -cyclobutanols and elemental sulfur has been developed. This protocol provides a strategy for constructing multisubstituted thiophene derivatives via C-S bond formation under air. This reaction shows good functionality tolerance under the reaction conditions, and the mechanism is validated by control experiments and density functional theory calculations.
