Zhuang Daijiao, Gatera Tharcisse, An Zhenyu, Yan Rulong
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Org Lett. 2022 Jan 21;24(2):771-775. doi: 10.1021/acs.orglett.1c04304. Epub 2022 Jan 5.
The synthesis of 1-pyrrolines from cyclobutanol derivatives and an aminating reagent (MsONHOTf) has been developed. This one-pot procedure achieves C-N bond/C═N bond formation via ring expansion. A series of 1-pyrroline derivatives are synthesized in moderate to good yields under mild conditions.
已开发出从环丁醇衍生物和胺化试剂（MsONHOTf）合成1-吡咯啉的方法。该一锅法通过扩环实现C-N键/C═N键的形成。在温和条件下以中等至良好的产率合成了一系列1-吡咯啉衍生物。
