• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Sex matters in the aging heart: implications for antifibrotic therapies.

作者信息

Garvin Alexandra M, Hale Taben M

机构信息

Department of Basic Medical Sciences, College of Medicine-Phoenix, University of Arizona, Phoenix, Arizona.

出版信息

Am J Physiol Heart Circ Physiol. 2022 Aug 1;323(2):H360-H361. doi: 10.1152/ajpheart.00340.2022. Epub 2022 Jul 15.

DOI:10.1152/ajpheart.00340.2022
PMID:35839153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9342135/
Abstract
摘要

相似文献

1
Sex matters in the aging heart: implications for antifibrotic therapies.性别对衰老心脏有影响:对抗纤维化治疗的启示。
Am J Physiol Heart Circ Physiol. 2022 Aug 1;323(2):H360-H361. doi: 10.1152/ajpheart.00340.2022. Epub 2022 Jul 15.
2
Distinct Regulation of Cardiac Fibroblast Proliferation and Transdifferentiation by Classical and Novel Protein Kinase C Isoforms: Possible Implications for New Antifibrotic Therapies.经典和新型蛋白激酶 C 同工型对心脏成纤维细胞增殖和转分化的不同调节:对新型抗纤维化治疗的可能影响。
Mol Pharmacol. 2021 Feb;99(2):104-113. doi: 10.1124/molpharm.120.000094. Epub 2020 Nov 25.
3
Differential Gender-Dependent Patterns of Cardiac Fibrosis and Fibroblast Phenotypes in Aging Mice.衰老小鼠心脏纤维化和成纤维细胞表型的性别依赖性差异。
Oxid Med Cell Longev. 2020 May 23;2020:8282157. doi: 10.1155/2020/8282157. eCollection 2020.
4
Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction.细胞外基质蛋白 1(ECM1)在心脏衰老和心肌梗死中的新作用。
PLoS One. 2019 Feb 21;14(2):e0212230. doi: 10.1371/journal.pone.0212230. eCollection 2019.
5
Visceral Adipose Tissue Drives Cardiac Aging Through Modulation of Fibroblast Senescence by Osteopontin Production.内脏脂肪组织通过骨桥蛋白产生调节成纤维细胞衰老来驱动心脏衰老。
Circulation. 2018 Aug 21;138(8):809-822. doi: 10.1161/CIRCULATIONAHA.117.031358.
6
Aicar treatment reduces interstitial fibrosis in aging mice: Suppression of the inflammatory fibroblast.Aicar 治疗可减少衰老小鼠的间质纤维化:抑制炎症成纤维细胞。
J Mol Cell Cardiol. 2017 Oct;111:81-85. doi: 10.1016/j.yjmcc.2017.08.003. Epub 2017 Aug 4.
7
Changes in cardiac resident fibroblast physiology and phenotype in aging.衰老中心房成纤维细胞生理学和表型的变化。
Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H745-H755. doi: 10.1152/ajpheart.00237.2018. Epub 2018 Jun 15.
8
Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.动态染色质靶向 BRD4 可刺激心脏成纤维细胞活化。
Circ Res. 2019 Sep 13;125(7):662-677. doi: 10.1161/CIRCRESAHA.119.315125. Epub 2019 Aug 14.
9
Silencing of UTX Mitigates Aging-Associated Cardiac Fibrosis via Blocking Cardiac Fibroblasts-to-Myofibroblasts Trans-Differentiation.UTX 沉默通过阻断心肌成纤维细胞向肌成纤维细胞的转分化减轻衰老相关的心脏纤维化。
Anatol J Cardiol. 2023 Jul 3;27(7):398-407. doi: 10.14744/AnatolJCardiol.2023.2777. Epub 2023 Jun 7.
10
Mechanisms and implications of sex differences in cardiac aging.心脏衰老中性别差异的机制及影响
J Cardiovasc Aging. 2022;2. doi: 10.20517/jca.2022.01. Epub 2022 Mar 16.

引用本文的文献

1
Sex-dependent Pathophysiology and Therapeutic Considerations in Right Heart Disease.右心疾病中的性别依赖性病理生理学及治疗考量
Can J Cardiol. 2025 Jun;41(6):1038-1053. doi: 10.1016/j.cjca.2025.02.034. Epub 2025 Mar 5.
2
Sex as a biological variable for cardiovascular physiology.性别作为心血管生理学的生物学变量。
Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H459-H469. doi: 10.1152/ajpheart.00727.2023. Epub 2023 Dec 15.
3
Guidelines on the use of sex and gender in cardiovascular research.心血管研究中性别和性别的使用指南。
Am J Physiol Heart Circ Physiol. 2024 Jan 1;326(1):H238-H255. doi: 10.1152/ajpheart.00535.2023. Epub 2023 Nov 24.
4
Fibroblasts under pressure: cardiac fibroblast responses to hypertension and antihypertensive therapies.受压的成纤维细胞:高血压及抗高血压治疗对心脏成纤维细胞的反应。
Am J Physiol Heart Circ Physiol. 2024 Jan 1;326(1):H223-H237. doi: 10.1152/ajpheart.00401.2023. Epub 2023 Nov 24.

本文引用的文献

1
Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis.衰老小鼠心脏中的性别特异性表型及其对慢性纤维化的影响。
Am J Physiol Heart Circ Physiol. 2022 Aug 1;323(2):H285-H300. doi: 10.1152/ajpheart.00078.2022. Epub 2022 Jun 17.
2
Sex similarities and differences in the reverse and anti-remodeling effect of pressure unloading therapy in a rat model of aortic banding and debanding.压力卸载治疗在主动脉缩窄和去缩窄大鼠模型中的逆转和抗重构作用的性别相似性和差异。
Am J Physiol Heart Circ Physiol. 2022 Jul 1;323(1):H204-H222. doi: 10.1152/ajpheart.00654.2021. Epub 2022 Jun 10.
3
Transient ACE (Angiotensin-Converting Enzyme) Inhibition Suppresses Future Fibrogenic Capacity and Heterogeneity of Cardiac Fibroblast Subpopulations.短暂性血管紧张素转换酶(ACE)抑制作用可抑制心脏成纤维细胞亚群的未来纤维化能力和异质性。
Hypertension. 2021 Mar 3;77(3):904-918. doi: 10.1161/HYPERTENSIONAHA.120.16352. Epub 2021 Jan 25.
4
Overexpression of laminin α4 facilitates proliferation and migration of fibroblasts in knee arthrofibrosis by targeting canonical Shh/Gli1 signaling.层粘连蛋白α4的过表达通过靶向经典的Shh/Gli1信号通路促进膝关节纤维性关节病中成纤维细胞的增殖和迁移。
Connect Tissue Res. 2021 Jul;62(4):464-474. doi: 10.1080/03008207.2020.1773451. Epub 2020 Jun 10.
5
Regulation of GLI1 by cis DNA elements and epigenetic marks.GLI1 的顺式 DNA 元件和表观遗传标记调控。
DNA Repair (Amst). 2019 Jul;79:10-21. doi: 10.1016/j.dnarep.2019.04.011. Epub 2019 May 2.
6
Effects of aging on cardiac extracellular matrix in men and women.衰老对男性和女性心脏细胞外基质的影响。
Proteomics Clin Appl. 2016 Jan;10(1):84-91. doi: 10.1002/prca.201500031. Epub 2015 Sep 25.
7
AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction.AICAR 依赖性 AMPK 激活可改善再灌注心肌梗死小鼠模型中衰老心脏的瘢痕形成。
J Mol Cell Cardiol. 2013 Oct;63:26-36. doi: 10.1016/j.yjmcc.2013.07.005. Epub 2013 Jul 19.
8
Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation.基质金属蛋白酶-28 缺失通过抑制 M2 巨噬细胞激活加剧心肌梗死后小鼠的心脏功能障碍和破裂。
Circ Res. 2013 Feb 15;112(4):675-88. doi: 10.1161/CIRCRESAHA.111.300502. Epub 2012 Dec 20.
9
Expression and function of matrix metalloproteinase (MMP)-28.基质金属蛋白酶(MMP)-28的表达与功能
Matrix Biol. 2009 Jun;28(5):263-72. doi: 10.1016/j.matbio.2009.04.006. Epub 2009 Apr 16.