The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Metal Disorders, Guangzhou, China.
The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Metal Disorders, Guangzhou, China.
J Psychiatr Res. 2022 Sep;153:189-196. doi: 10.1016/j.jpsychires.2022.07.001. Epub 2022 Jul 9.
Suicide is a common issue among major depressive disorder (MDD) patients and suicidal ideation (SI) is the first step toward it. There are no definitive objective biomarkers of SI relative to MDD. In this study, a seed-based correlation analysis was performed among 36 MDD patients with SI, 66 MDD patients without SI (NSI), and 57 healthy controls (HCs) using amygdala resting-state functional connectivity (RSFC). Furthermore, the correlation between amygdala RSFC and clinical features was examined in the SI group. When compared to the NSI group, SI group exhibited increased RSFC between the left amygdala seed and left medial superior frontal gyrus (SFGmed) as well as left middle frontal gyrus (MFG). In turn, a decreased RSFC was observed between the left amygdala seed and the following brain regions including the left inferior parietal lobule (IPL), right precentral gyrus (PrCG), and left superior parietal lobule (SPL) in SI group compared to NSI group. Moreover, the SI group exhibited increased RSFC of the right amygdala with left middle temporal gyrus (MTG); In addition, the RSFC of the left amygdala with left MFG was negatively associated with learning and memory (VSM), speed of processing (SOP). The RSFC of the amygdala is distinct between MDD patients with SI and without SI. Our findings reveal the neurobiological characteristics of MDD with respect to SI and provide new clues regarding vulnerability to mental illness. It is necessary to carry out repeated and more longitudinal researches using multimodal approaches on SI in the future.
自杀是重度抑郁症（MDD）患者的常见问题，自杀意念（SI）是其第一步。目前尚无针对 MDD 的 SI 的明确客观生物标志物。在这项研究中，对 36 名有 SI 的 MDD 患者、66 名无 SI（NSI）的 MDD 患者和 57 名健康对照者（HCs）进行了基于种子的杏仁核静息态功能连接（RSFC）相关分析。此外，还在 SI 组中检查了杏仁核 RSFC 与临床特征之间的相关性。与 NSI 组相比，SI 组的左杏仁核种子与左侧内侧额上回（SFGmed）和左侧额中回（MFG）之间的 RSFC 增加，而左侧杏仁核种子与左顶下小叶（IPL）、右中央前回（PrCG）和左侧顶上小叶（SPL）之间的 RSFC 减少。此外，与 NSI 组相比，SI 组的右侧杏仁核与左侧颞中回（MTG）之间的 RSFC 增加；此外，左侧杏仁核与左侧额中回（MFG）之间的 RSFC 与学习和记忆（VSM）、加工速度（SOP）呈负相关。有 SI 和无 SI 的 MDD 患者的杏仁核 RSFC 存在差异。我们的研究结果揭示了 MDD 患者 SI 的神经生物学特征，并为精神疾病易感性提供了新的线索。未来有必要采用多模态方法对 SI 进行重复性更强和更长期的研究。
