Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Department of Acupuncture and Massage, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Sci Rep. 2022 Jul 15;12(1):12089. doi: 10.1038/s41598-022-16010-y.
To determine whether there is a link between serum albumin and mortality among participants in the elderly in Japan. This is a single-center,retrospective cohort study analysis of 253 old patients with dysphagia from Japan, conducted from January 2014 to January 2017. The primary outcome was mortality. We performed Cox regression analysis to compare the mortality between the two groups (divided by serum albumin = 3 g/dl). 253 patients were included in the analysis, of whom the number of serum albumin under 3 g/dl was 93. The log-rank test showed a significant longer mortality in the high group (serum albumin > = 3 g/dl) compared with the low group (median, 382 vs. 176 days, P < 0.0001). Cox regression analysis showed that unadjusted HR for the high group relative to the low group was 0.40 (95% CI: 0.29-0.57; P < 0.001). After adjusting 3 models in multivariable analysis, serum albumin was significantly associated with mortality. The adjusted HRs (95% CI) for total mortality rates were 0.46 (0.33-0.65), 0.66 (0.44-0.99) and 0.64 (0.42-0.97), from model 2 to model 4. There is negative association between serum albumin and mortality in Japanese old people with dysphagia.
确定血清白蛋白与日本老年人参与者死亡率之间是否存在关联。这是一项对 2014 年 1 月至 2017 年 1 月期间来自日本的 253 名吞咽困难老年患者进行的单中心回顾性队列研究分析。主要结局是死亡率。我们进行 Cox 回归分析比较两组之间的死亡率（按血清白蛋白=3g/dl 划分）。纳入 253 例患者，其中血清白蛋白<3g/dl 的患者有 93 例。对数秩检验显示，高组（血清白蛋白≥3g/dl）的死亡率明显长于低组（中位数：382 与 176 天，P<0.0001）。Cox 回归分析显示，未调整的高组与低组的 HR 为 0.40（95%CI：0.29-0.57；P<0.001）。在多变量分析中调整 3 个模型后，血清白蛋白与死亡率显著相关。全因死亡率的调整后 HR（95%CI）分别为 0.46（0.33-0.65）、0.66（0.44-0.99）和 0.64（0.42-0.97），从模型 2 到模型 4。在日本有吞咽困难的老年人中，血清白蛋白与死亡率呈负相关。
