Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, 518028, China.
School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen, 518107, China.
Environ Sci Pollut Res Int. 2022 Dec;29(59):88779-88787. doi: 10.1007/s11356-022-21965-6. Epub 2022 Jul 15.
The potential hazards of polycyclic aromatic hydrocarbons (PAHs) on fetus development have raised widespread concerns in recent years, although current epidemiological findings are conflicting. The aim of this case-control study was to investigate the relationship between PAH concentrations in maternal serum and low birth weight (LBW). A questionnaire survey was conducted among 144 (72 pairs) neonates with normal or LBW and their mothers at four different hospitals in Shenzhen, China. Peripheral blood from primiparas and umbilical cord blood from neonates were collected. Concentrations of PAHs were determined by gas chromatography-mass spectrometry. The detection frequencies of PAHs were relatively higher in the peripheral blood samples, while levels of low molecular weight PAHs were greater than high molecular weight PAHs in both peripheral and umbilical cord blood samples. Phenanthrene was frequently detected in blood samples from the case and control groups. Logistic regression analysis showed that acenaphthene in peripheral blood was positively associated with LBW (p < 0.05). This study found a relationship between exposure to certain PAHs and LBW, although future studies are needed to confirm these results.
近年来，多环芳烃 (PAHs) 对胎儿发育的潜在危害引起了广泛关注，尽管目前的流行病学研究结果存在矛盾。本病例对照研究旨在探讨母体血清中 PAH 浓度与低出生体重 (LBW) 的关系。在中国深圳的四家医院，对 144 名（72 对）正常体重或 LBW 的新生儿及其母亲进行了问卷调查。采集初产妇外周血和新生儿脐血。采用气相色谱-质谱法测定 PAHs 浓度。外周血样本中 PAHs 的检出频率相对较高，而在母血和脐血样本中，低分子量 PAHs 的水平均高于高分子量 PAHs。菲是病例组和对照组血样中经常检测到的物质。Logistic 回归分析显示，外周血中的苊与 LBW 呈正相关（p<0.05）。本研究发现某些 PAHs 的暴露与 LBW 之间存在关联，但需要进一步的研究来证实这些结果。
