牛松果体器官和视网膜的糖脂。

Glycolipids of the bovine pineal organ and retina.

作者信息

Matsui E, Ogura K, Handa S

出版信息

J Biochem. 1987 Feb;101(2):423-32. doi: 10.1093/oxfordjournals.jbchem.a121927.

DOI:10.1093/oxfordjournals.jbchem.a121927

Abstract

Neutral and acidic glycolipids from the bovine pineal organ and neutral glycolipids from the bovine retina were characterized. The chemical structures of the isolated glycolipids were determined by means of carbohydrate analysis, methylation analysis, enzyme treatment, fatty acid analysis, long chain base analysis, mass spectrometry, NMR spectroscopy, and IR spectroscopy. GM3, GD3, and GT1 were the major bovine pineal organ gangliosides, GD3 accounting for 75% of the total gangliosides. Galactosylceramide, glucosylceramide, and lactosylceramide were found in both the bovine pineal organ and retina. Sulfatide was also present in both tissues. It had already been reported that the major bovine retina ganglioside was GD3 (Handa, S. & Burton, R.M. (1969) Lipids 4, 205-208). The glycolipid patterns of the two tissues were very similar to each other and quite different from those of other tissues.

摘要

对来自牛松果体器官的中性和酸性糖脂以及来自牛视网膜的中性糖脂进行了表征。通过碳水化合物分析、甲基化分析、酶处理、脂肪酸分析、长链碱基分析、质谱、核磁共振光谱和红外光谱确定了分离出的糖脂的化学结构。GM3、GD3和GT1是牛松果体器官的主要神经节苷脂，GD3占总神经节苷脂的75%。在牛松果体器官和视网膜中均发现了半乳糖基神经酰胺、葡萄糖基神经酰胺和乳糖基神经酰胺。两种组织中也都存在硫脂。已有报道称，牛视网膜的主要神经节苷脂是GD3（Handa，S.和Burton，R.M.（1969年）《脂质》4，205 - 208）。这两种组织的糖脂模式彼此非常相似，与其他组织的模式有很大不同。