Infection Control Programme and WHO Collaborating Center on Infection Prevention and Control and Antimicrobial Resistance, University of Geneva Hospitals and Faculty of Medicine, 4 Rue Gabrielle-Perret-Gentil, 1211, Geneva 14, Switzerland.
University of Geneva, Geneva, Switzerland.
Antimicrob Resist Infect Control. 2022 Jul 15;11(1):97. doi: 10.1186/s13756-022-01129-4.
Healthcare workers often experience skin dryness and irritation from performing hand hygiene frequently. Low acceptability and tolerability of a formulation are barriers to hand hygiene compliance, though little research has been conducted on what specific types of formulation have higher acceptability than others.
To compare the acceptability and tolerability of an ethanol-based handrub gel with superfatting agents to the isopropanol-based formulations (a rub and a gel formulation) currently used by healthcare workers at the University of Geneva Hospitals, Geneva, Switzerland.
Forty-two participants were randomized to two sequences, testing the isopropanol-based formulation that they are using currently (Hopirub® or Hopigel®), and the ethanol-based formulation containing superfatting agents (Saniswiss Sanitizer Hands H1). Participants tested each of the formulations over 7-10 day work shifts, after which skin condition was assessed and feedback was collected.
H1 scored significantly better than the control formulations for skin dryness (P = 0.0209), and participants felt less discomfort in their hands when using that formulation (P = 0.0448). H1 caused less skin dryness than Hopirub®/Hopigel® (P = 0.0210). Though overall preference was quite polarized, 21 participants preferred H1 intervention formulation and 17 preferred the Hopirub®/Hopigel® formulation that they normally used in their care activities.
We observed a difference in acceptability and strongly polarized preferences among the participants' reactions to the formulations tested. These results indicate that giving healthcare workers a choice between different high-quality products is important to ensure maximum acceptability.
医护人员频繁进行手部卫生清洁时常会出现皮肤干燥和刺激问题。尽管针对何种配方的制剂更易被接受这一问题的研究甚少，但制剂的可接受性和耐受性低仍是手部卫生依从性的障碍。
比较含超脂剂的乙醇基手部搓揉凝胶与目前日内瓦大学附属医院医护人员使用的异丙醇基制剂（一种搓揉剂和一种凝胶制剂）的可接受性和耐受性。
42 名参与者随机分为两组，分别测试他们目前正在使用的异丙醇基制剂（Hopirub®或 Hopigel®）和含超脂剂的乙醇基制剂（Saniswiss Sanitizer Hands H1）。参与者在 7-10 个工作日的轮班中测试了每种制剂，之后评估皮肤状况并收集反馈。
H1 在皮肤干燥方面的评分明显优于对照制剂（P=0.0209），且参与者在使用该制剂时手部不适感更轻（P=0.0448）。H1 引起的皮肤干燥程度低于 Hopirub®/Hopigel®（P=0.0210）。尽管总体偏好差异较大，但有 21 名参与者更喜欢 H1 干预制剂，17 名参与者更喜欢他们在护理活动中通常使用的 Hopirub®/Hopigel®制剂。
我们观察到参与者对测试制剂的反应在可接受性方面存在差异，且偏好呈两极分化。这些结果表明，为医护人员提供不同优质产品之间的选择对于确保最大可接受性非常重要。
