Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Instituto Alfa de Gastroenterologia, Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Transpl Immunol. 2022 Oct;74:101671. doi: 10.1016/j.trim.2022.101671. Epub 2022 Jul 13.
Acute hepatitis presenting with blood eosinophilia are scarcely reported. Different clinical courses of autoimmune hepatitis (AIH) have been associated with acute hepatitis with eosinophilia, however it is still unclear if the latter is a common manifestation of different autoimmune diseases, part of a similar spectrum of eosinophil-associated liver injury or even a trigger to AIH. We report a case of a 32 years old woman who presented with subacute hepatitis, peripheral eosinophilia, hypergammaglobulinemia and liver biopsy suggestive of AIH. The role of eosinophils in autoimmune liver diseases deserves further studies in order to clarify its physiopathology aspects.
急性肝炎伴嗜酸粒细胞增多症少见报道。不同的自身免疫性肝炎（AIH）临床病程与嗜酸粒细胞性肝炎相关，但目前尚不清楚后者是否是不同自身免疫性疾病的常见表现，是否属于相似的嗜酸性粒细胞相关肝损伤谱的一部分，甚至是否是 AIH 的触发因素。我们报告了一例 32 岁女性，表现为亚急性肝炎、外周血嗜酸粒细胞增多、高球蛋白血症和肝活检提示 AIH。嗜酸粒细胞在自身免疫性肝病中的作用值得进一步研究，以阐明其病理生理方面。
