Faure H, Peyrin J C, Favier A
J Chir (Paris). 1987 Mar;124(3):184-8.
It is well established that blood zinc concentrations fall postoperatively but documented data does not exist proving a direct relation between the fall in levels and the serious or otherwise nature of surgery performed. This relation was investigated in 25 patients, distributed into three groups as a function of severity of operation, by determining total serum zinc and also its distribution amongst vector proteins and amino acids. Findings indicated that minor procedures such as leg varicose vein stripping failed to affect blood zinc whereas major surgery (extracorporeal circulation) provoked a fall of 47% in blood zinc levels. In addition, this reduction affected only the exchangeable fraction (which is therefore the only one biologically active) of serum zinc. This suggests the need for zinc supplementation to assist healing and re-establish immunity phenomena after major surgery.
术后血锌浓度会下降，这一点已得到充分证实，但尚无文献数据能够证明血锌水平下降与所实施手术的严重程度或其他性质之间存在直接关联。本研究对25例患者进行了调查，根据手术严重程度将患者分为三组，通过测定血清总锌及其在载体蛋白和氨基酸中的分布情况来研究这种关系。研究结果表明，诸如腿部静脉曲张剥脱术等小手术不会影响血锌水平，而大手术（体外循环）则会使血锌水平下降47%。此外，这种降低仅影响血清锌的可交换部分（因此这是唯一具有生物活性的部分）。这表明在大手术后需要补充锌以促进愈合并重建免疫现象。
