Faure H, Peyrin J C, Richard M J, Favier A
Laboratoire de Biochimie C, Centre Hospitalier Régional, Grenoble, France.
Biol Trace Elem Res. 1991 Jul;30(1):37-45. doi: 10.1007/BF02990340.
Zinc has been known for a long time to facilitate wound healing. But, so far, supplementation trials in patients treated by major severity surgery gave either partial or controversial results. In a double-blind, randomized study including 30 patients, we show that zinc supplements (30 mg/d for 3 d) administered by a drip correct postoperative drop of serum zinc, that this correction concerns the available part of serum zinc (i.e., zinc that is bound to compounds other than alpha-2 macroglobulin in serum), and that this supplementation can improve clinical wound healing. Possible influence of increased urinary output after the intervention is discussed, and we found that serum cortisol remains stable when zinc/albumin ratio is stable, and increases sharply when the same ratio drops. Cortisol, therefore, seems to play a major role in zinc redistribution after surgery.
长期以来，人们都知道锌有助于伤口愈合。但是，到目前为止，在接受大手术治疗的患者中进行的补充试验结果要么不完整，要么存在争议。在一项纳入30名患者的双盲随机研究中，我们发现通过静脉滴注给予锌补充剂（30毫克/天，共3天）可纠正术后血清锌水平的下降，这种纠正涉及血清锌的可利用部分（即血清中与α-2巨球蛋白以外的化合物结合的锌），并且这种补充可以改善临床伤口愈合。文中讨论了干预后尿量增加的可能影响，我们发现当锌/白蛋白比值稳定时血清皮质醇保持稳定，而当该比值下降时血清皮质醇会急剧增加。因此，皮质醇似乎在术后锌的重新分布中起主要作用。
