Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou, 215123, PR China.
Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou, 215123, PR China.
Nutr Metab Cardiovasc Dis. 2022 Sep;32(9):2204-2215. doi: 10.1016/j.numecd.2022.05.020. Epub 2022 May 30.
The visceral adiposity index (VAI) has been recently established as a measure of visceral fat distribution and is shown to be associated with a wide range of adverse health events. However, the precise associations between the VAI score and all-cause and cause-specific mortalities in the general population remain undetermined.
In this large-scale prospective epidemiological study, 357,457 participants (aged 38-73 years) were selected from the UK Biobank. We used Cox competing risk regression models to estimate the association between the VAI score and all-cause, cardiovascular disease (CVD), cancer, and other mortalities. The VAI score was significantly correlated with an increased risk of all-cause mortality (hazard ratio [HR], 1.200; 95% confidence interval [CI], 1.148-1.255; P < 0.0001), cancer mortality (HR, 1.224; 95% CI, 1.150-1.303; P < 0.0001), CVD mortality (HR, 1.459; 95% CI, 1.148-1.255; P < 0.0001), and other mortalities (HR, 1.200; 95% CI, 1.148-1.255; P < 0.0001) after adjusting for a series of confounders. In addition, the subgroup analyses showed that HRs were significantly higher in participants who were male, aged below 65 years, and body mass index less than 25.
In summary, VAI was positively associated with an increased risk of all-cause and cause-specific mortalities in a nationwide, well-characterised population identified in a UK Biobank. The VAI score might be a complementary traditional predictive indicator for evaluating the risk of adverse health events in the population of Western adults aged 38 years and older.
内脏脂肪指数（VAI）最近被确立为衡量内脏脂肪分布的指标，并且与广泛的不良健康事件相关。然而，VAI 评分与一般人群全因和特定原因死亡率之间的确切关联仍未确定。
在这项大规模的前瞻性流行病学研究中，从英国生物库中选择了 357457 名参与者（年龄 38-73 岁）。我们使用 Cox 竞争风险回归模型来估计 VAI 评分与全因、心血管疾病（CVD）、癌症和其他死亡率之间的关联。VAI 评分与全因死亡率（危险比[HR]，1.200；95%置信区间[CI]，1.148-1.255；P<0.0001）、癌症死亡率（HR，1.224；95%CI，1.150-1.303；P<0.0001）、CVD 死亡率（HR，1.459；95%CI，1.148-1.255；P<0.0001）和其他死亡率（HR，1.200；95%CI，1.148-1.255；P<0.0001）显著相关，在调整了一系列混杂因素后。此外，亚组分析表明，在男性、年龄低于 65 岁和 BMI 低于 25 的参与者中，HR 显著更高。
总之，VAI 与英国生物库中确定的全国性、特征良好的人群的全因和特定原因死亡率增加呈正相关。VAI 评分可能是评估西方成年人（年龄 38 岁及以上）人群不良健康事件风险的传统预测指标的补充。
