Parra-Soto Solange, Boonpor Jirapitcha, Lynskey Nathan, Araya Carolina, Ho Frederick, Pell Jill P, Celis-Morales Carlos
Department of Nutrition and Public Health, Faculty of Health and Food Science, Universidad del Bío-Bío, Chillan, Chile.
School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Cancer. 2025 Jan 1;131(1):e35576. doi: 10.1002/cncr.35576. Epub 2024 Oct 3.
The visceral adiposity index (VAI) is a marker of visceral fat accumulation and metabolic dysfunction, but there is limited evidence of its association with cancer. The objective of this study was to investigate associations between the VAI and both incident cancer at 23 sites and all-cause cancer.
In total, 385,477 participants (53.3% women; mean age, 56.3 years) from the UK Biobank prospective cohort were included in this study. The median follow-up was 8.2 years (interquartile range, 7.3-8.9 years). The VAI was calculated using formula the published by Amato et al. and was categorized into sex-specific tertiles. Twenty-four incident cancers were the outcomes. Cox proportional hazard models were adjusted for sociodemographics, lifestyle factors, and multimorbidity counts.
Over the follow-up period, 47,882 individuals developed cancer. In the fully adjusted models, the VAI was associated with a higher risk of six cancer sites. Individuals in the highest tertile, compared with those in the lowest tertile, had higher risks of uterine (hazard ratio [HR], 2.09; 95% confidence interval [CI], 1.76-2.49), gallbladder (HR, 1.83; 95% CI, 1.26-2.66), kidney (HR, 1.39; 95% CI, 1.18-1.64), liver (HR, 1.25; 95% CI, 1.00-1.56), colorectal (HR, 1.14; 95% CI, 1.05-1.24), and breast (HR, 1.11; 95% CI, 1.03-1.19) cancers and of all-cause cancer (HR, 1.05). There was no evidence of a nonlinear association between the VAI and cancer risk.
The VAI was associated with six cancer sites and with all-cause cancer. The prognostic and etiologic roles of visceral fat accumulation and dysfunction in cancer warrant further research.
内脏脂肪指数（VAI）是内脏脂肪堆积和代谢功能障碍的一个标志物，但关于其与癌症关联的证据有限。本研究的目的是调查VAI与23个部位的新发癌症以及全因癌症之间的关联。
本研究纳入了英国生物银行前瞻性队列中的385477名参与者（53.3%为女性；平均年龄56.3岁）。中位随访时间为8.2年（四分位间距为7.3 - 8.9年）。VAI使用Amato等人发表的公式计算，并按性别分为三分位数。24种新发癌症为研究结局。Cox比例风险模型对社会人口统计学、生活方式因素和多种疾病计数进行了调整。
在随访期间，47882人患癌症。在完全调整模型中，VAI与6个癌症部位的较高风险相关。与最低三分位数的个体相比，最高三分位数的个体患子宫癌（风险比[HR]为2.09；95%置信区间[CI]为1.76 - 2.49）、胆囊癌（HR为1.83；95% CI为1.26 - 2.66）、肾癌（HR为1.39；95% CI为1.18 - 1.64）、肝癌（HR为1.25；95% CI为1.00 - 1.56）、结直肠癌（HR为1.14；95% CI为1.05 - 1.24）、乳腺癌（HR为1.11；95% CI为1.03 - 1.19）以及全因癌症（HR为1.05）的风险更高。没有证据表明VAI与癌症风险之间存在非线性关联。
VAI与6个癌症部位以及全因癌症相关。内脏脂肪堆积和功能障碍在癌症中的预后和病因学作用值得进一步研究。
