Cao C, Shao Y K, Yao Q Y
Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2022 Jul 25;25(7):648-653. doi: 10.3760/cma.j.cn441530-20210903-00356.
Gut microbiota have been validated to play a pivotal role in metabolic regulation. As the most effective treatment for obesity and related comorbidities, bariatric surgery has been shown to result in significant alterations to the gut microbiota. Literature have recently suggested temporal and spatial features of alterations to the intestinal bacteria following bariatric surgery, which is possibly attributed to the gut adaptation to the surgical modification on the gastrointestinal tract. More importantly, the gut microbiota have been appreciated as a critical contributor to the metabolic improvements following bariatric surgery. Although not fully elucidated, the underlying mechanisms are associated with the molecular pathways mediating the crosstalk between gut microbiota and host . On the other hand, change of the gut microbiota has been found to be related to the prognosis of patients receiving bariatric surgery. Some studies even point out negative effects of the gut microbiota on certain surgical complications . In this review, we summarize the characteristics of alterations to the gut microbiota following bariatric surgery as well as its relevant impacts to better understand the role of gut microbiota in bariatric surgery.
肠道微生物群已被证实对代谢调节起着关键作用。作为肥胖及其相关合并症最有效的治疗方法，减肥手术已被证明会导致肠道微生物群发生显著变化。最近的文献表明了减肥手术后肠道细菌变化的时空特征，这可能归因于肠道对胃肠道手术改变的适应。更重要的是，肠道微生物群被认为是减肥手术后代谢改善的关键因素。尽管尚未完全阐明，但其潜在机制与介导肠道微生物群与宿主之间相互作用的分子途径有关。另一方面，已发现肠道微生物群的变化与接受减肥手术患者的预后有关。一些研究甚至指出肠道微生物群对某些手术并发症的负面影响。在本综述中，我们总结了减肥手术后肠道微生物群变化的特征及其相关影响，以更好地了解肠道微生物群在减肥手术中的作用。
