Department of General Surgery, Kafkas University Faculty of Medicine, Kars, Turkey.
Department of Medical Biochemistry, Kafkas University Faculty of Medicine, Kars, Turkey.
Obesity (Silver Spring). 2022 Aug;30(8):1639-1646. doi: 10.1002/oby.23471. Epub 2022 Jul 18.
This study aimed to reveal the relationship between obesity and asprosin (fibrillin-1) in patients undergoing bariatric surgery and to investigate the role of asprosin in obesity etiopathogenesis.
The study included 37 patients who underwent laparoscopic sleeve gastrectomy for severe obesity and 37 patients who underwent laparoscopic cholecystectomy for cholelithiasis in the study and control groups, respectively. Blood samples were collected from the patients in the preoperative period to measure biochemical parameters. Blood samples were collected at 6 months postoperatively from the patients in the study group to compare their pre- and postoperative serum asprosin levels.
A significant intergroup difference in terms of mean asprosin levels in adipose tissue was noted (p = 0.001). A comparison of preoperative and postoperative 6-month serum asprosin levels in the study group showed significant differences (p = 0.021). The area under the curve of asprosin tissue levels was 78.1%, and the cutoff value was 217.34 ng/g of protein, with a sensitivity and specificity of 73.0%. Tissue levels of asprosin were found to increase the risk of obesity by a factor of 1.018 (odds ratio; 95% CI: 1.008-1.027).
Serum asprosin levels decreased significantly at 6 months after bariatric surgery. Adipose tissue of patients with obesity showed high asprosin levels and immunoreactivity. In conclusion, asprosin levels in adipose tissue were considered a potential independent risk factor in obesity etiopathogenesis.
本研究旨在揭示肥胖症患者接受减重手术后肥胖症与阿普司林（原纤维蛋白 1）之间的关系，并探讨阿普司林在肥胖症发病机制中的作用。
研究纳入了 37 例因严重肥胖症而行腹腔镜袖状胃切除术的患者（研究组）和 37 例因胆石症而行腹腔镜胆囊切除术的患者（对照组）。分别于术前和术后 6 个月采集两组患者的血样，以测量生化参数。
两组患者的脂肪组织平均阿普司林水平存在显著的组间差异（p=0.001）。与术前相比，研究组患者术后 6 个月的血清阿普司林水平有显著差异（p=0.021）。阿普司林组织水平的曲线下面积为 78.1%，截距值为 217.34ng/g 蛋白，灵敏度和特异性分别为 73.0%。阿普司林组织水平使肥胖的风险增加了 1.018 倍（优势比；95%置信区间：1.008-1.027）。
减重手术后 6 个月时，血清阿普司林水平显著下降。肥胖症患者的脂肪组织表现出高阿普司林水平和免疫反应性。总之，脂肪组织中的阿普司林水平被认为是肥胖症发病机制中的一个潜在的独立危险因素。
