Kulcsarova Kristina, Baloghova Janette, Necpal Jan, Skorvanek Matej
Department of Neurology, Medical Faculty University of Pavol Jozef Safarik Pavol Slovak Republic.
Department of Neurology University Hospital L. Pasteur Kosice Slovak Republic.
Mov Disord Clin Pract. 2022 Mar 24;9(5):566-583. doi: 10.1002/mdc3.13436. eCollection 2022 Jul.
Skin manifestations are well-recognized non-motor symptoms of Parkinson's disease (PD) and other hypokinetic and hyperkinetic movement disorders. Skin conditions are usually well visible during routine clinical examination and their recognition may play a major role in diagnostic work-up. In this educational review we: (1) briefly outline skin conditions related to Parkinson's disease, including therapy-related skin complications and their management; (2) discuss the role of skin biopsies in early diagnosis of PD and differential diagnosis of parkinsonian syndromes; and focus more on areas which have not been reviewed in the literature before, including (3) skin conditions related to atypical parkinsonism, and (4) skin conditions related to hyperkinetic movement disorders. In case of rare hyperkinetic movement disorders, specific dermatological manifestations, like presence of angiokeratomas, telangiectasias, Mongolian spots, lipomas, ichthyosis, progeroid skin changes and others may point to a very specific group of disorders and help guide further investigations.
皮肤表现是帕金森病（PD）以及其他运动减少和运动增多性运动障碍公认的非运动症状。皮肤状况在常规临床检查中通常很容易看到，对其识别可能在诊断检查中起主要作用。在这篇教育综述中，我们：（1）简要概述与帕金森病相关的皮肤状况，包括与治疗相关的皮肤并发症及其管理；（2）讨论皮肤活检在帕金森病早期诊断和帕金森综合征鉴别诊断中的作用；并更多地关注以前文献中未涉及的领域，包括（3）与非典型帕金森病相关的皮肤状况，以及（4）与运动增多性运动障碍相关的皮肤状况。对于罕见的运动增多性运动障碍，特定的皮肤表现，如血管角皮瘤、毛细血管扩张、蒙古斑、脂肪瘤、鱼鳞病、早老样皮肤改变等的存在，可能指向一组非常特定的疾病，并有助于指导进一步的检查。
