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分化型甲状腺癌全切术后首次放射性碘治疗前后的动态免疫功能变化

Dynamic Immune Function Changes Before and After the First Radioactive Iodine Therapy After Total Resection of Differentiated Thyroid Carcinoma.

作者信息

Shi Zhi-Yong, Zhang Sheng-Xiao, Fan Di, Li Cai-Hong, Cheng Zhe-Hao, Xue Yan, Wu Li-Xiang, Lu Ke-Yi, Yang Su-Yun, Cheng Yan, Wu Zhi-Fang, Gao Chong, Li Xiao-Feng, Liu Hai-Yan, Li Si-Jin

机构信息

Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, China.

Collaborative Innovation Center for Molecular Imaging of Precision Medicine, First Hospital of Shanxi Medical University, Taiyuan, China.

出版信息

Front Immunol. 2022 Jun 30;13:901263. doi: 10.3389/fimmu.2022.901263. eCollection 2022.

DOI:10.3389/fimmu.2022.901263
PMID:35844520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9280633/
Abstract

The effects of total thyroidectomy or radioactive iodine therapy on immune activation and suppression of the tumor microenvironment remain unknown. We aimed to investigate the effects of these treatments on the immune function in patients with differentiated thyroid carcinoma (DTC). Our cohort included 45 patients with DTC treated with total thyroidectomy and radioactive iodine therapy (RAIT). Immune function tests were performed by flow cytometry at 0, 30, and 90 days post-RAIT. Both the percentage and absolute number of circulating regulatory T cells were significantly lower in the postoperative DTC compared to the healthy controls. Notably, the absolute number of multiple lymphocyte subgroups significantly decreased at 30 days post-RAIT compared to those pre-RAIT. The absolute counts of these lymphocytes were recovered at 90 days post-RAIT, but not at pre-RAIT levels. Additionally, the Th17 cell percentage before RAIT was positively correlated with thyroglobulin (Tg) levels after RAIT. The tumor burden might contribute to increased levels of circulating Tregs. In conclusion, RAIT caused transient radiation damage in patients with DTC and the percentage of Th17 cells before RAIT could be a significant predictor of poor prognosis in patients with DTC.

摘要

全甲状腺切除术或放射性碘治疗对肿瘤微环境免疫激活和抑制的影响尚不清楚。我们旨在研究这些治疗对分化型甲状腺癌（DTC）患者免疫功能的影响。我们的队列包括45例接受全甲状腺切除术和放射性碘治疗（RAIT）的DTC患者。在RAIT后0、30和90天通过流式细胞术进行免疫功能测试。与健康对照相比，术后DTC患者循环调节性T细胞的百分比和绝对数量均显著降低。值得注意的是，与RAIT前相比，RAIT后30天多个淋巴细胞亚群的绝对数量显著减少。这些淋巴细胞的绝对计数在RAIT后90天恢复，但未恢复到RAIT前水平。此外，RAIT前Th17细胞百分比与RAIT后甲状腺球蛋白（Tg）水平呈正相关。肿瘤负荷可能导致循环Tregs水平升高。总之，RAIT对DTC患者造成了短暂的辐射损伤，RAIT前Th17细胞百分比可能是DTC患者预后不良的重要预测指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e9/9280633/d2cebef69f7c/fimmu-13-901263-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e9/9280633/4c09a079e60b/fimmu-13-901263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e9/9280633/2c4aa56cf320/fimmu-13-901263-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e9/9280633/70a6b432964a/fimmu-13-901263-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e9/9280633/d2cebef69f7c/fimmu-13-901263-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e9/9280633/4c09a079e60b/fimmu-13-901263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e9/9280633/2c4aa56cf320/fimmu-13-901263-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e9/9280633/70a6b432964a/fimmu-13-901263-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e9/9280633/d2cebef69f7c/fimmu-13-901263-g004.jpg

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