Gao Mengjia, Xin Jingxin, Li Xiaoling, Gao Ling, Shao Shanshan, Zhao Meng
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.
Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong 250021, China.
Gastroenterol Res Pract. 2022 Jul 7;2022:3200932. doi: 10.1155/2022/3200932. eCollection 2022.
Nonalcoholic steatohepatitis (NASH) is a liver disease caused by multiple factors, and there is no approved pharmacotherapy. The pathogenesis of NASH remains underexplored. In this study, differentially expressed circular RNAs (circRNAs) were obtained by analyzing NASH-related circRNA datasets, and then, corresponding target microRNAs (miRNAs) and messenger RNAs (mRNAs) were predicted to construct a circRNA-miRNA-mRNA regulatory network. On this basis, a total of 38 circRNAs, 7 miRNAs, and 10 mRNAs were screened out. The present study reveals novel circRNA biomarkers of NASH and reports a potential competing endogenous RNA (ceRNA) regulatory network that might provide insights for further investigation into the underlying pathogenesis of NASH.
非酒精性脂肪性肝炎（NASH）是一种由多种因素引起的肝脏疾病，目前尚无获批的药物治疗方法。NASH的发病机制仍未得到充分研究。在本研究中，通过分析与NASH相关的环状RNA（circRNA）数据集获得差异表达的circRNA，然后预测相应的靶微小RNA（miRNA）和信使RNA（mRNA），构建circRNA-miRNA-mRNA调控网络。在此基础上，共筛选出38个circRNA、7个miRNA和10个mRNA。本研究揭示了NASH新的circRNA生物标志物，并报道了一个潜在的竞争性内源RNA（ceRNA）调控网络，这可能为进一步研究NASH的潜在发病机制提供思路。
