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Shelter from the storm: Acetaminophen (paracetamol) in pregnancy, urogenital malformations, and childhood neurodevelopment.

作者信息

Damkier Per, Hodson Kenneth

机构信息

Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark.

Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

出版信息

Obstet Med. 2022 Jun;15(2):77-78. doi: 10.1177/1753495X221080883. Epub 2022 Feb 22.

DOI:10.1177/1753495X221080883
PMID:35845231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9277736/
Abstract
摘要

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Shelter from the storm: Acetaminophen (paracetamol) in pregnancy, urogenital malformations, and childhood neurodevelopment.暴风雨中的庇护所：孕期对乙酰氨基酚（扑热息痛）、泌尿生殖系统畸形与儿童神经发育
Obstet Med. 2022 Jun;15(2):77-78. doi: 10.1177/1753495X221080883. Epub 2022 Feb 22.
2
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Paracetamol during pregnancy: no particular danger for the child.孕期服用对乙酰氨基酚：对胎儿无特殊危害。
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Paracetamol use during pregnancy and attention and executive function in offspring at age 5 years.孕期对乙酰氨基酚的使用与5岁后代的注意力及执行功能
Int J Epidemiol. 2016 Dec 1;45(6):2009-2017. doi: 10.1093/ije/dyw296.
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Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled cohort study.产前对乙酰氨基酚暴露与儿童神经发育：一项同胞对照队列研究。
Int J Epidemiol. 2013 Dec;42(6):1702-13. doi: 10.1093/ije/dyt183. Epub 2013 Oct 24.
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Use of acetaminophen (paracetamol) during pregnancy and the risk of attention-deficit/hyperactivity disorder in the offspring.孕期使用对乙酰氨基酚（扑热息痛）与后代患注意力缺陷多动障碍的风险
J Clin Psychiatry. 2016 Mar;77(3):e312-4. doi: 10.4088/JCP.16f10721.

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Acetaminophen in Pregnancy: A Population-Level Drug-Utilization Study of Prescription-Based Acetaminophen Use Among Pregnant Women in Denmark From 2001 to 2023.孕期对乙酰氨基酚：一项基于丹麦2001年至2023年孕妇处方类对乙酰氨基酚使用情况的人群水平药物利用研究。
Basic Clin Pharmacol Toxicol. 2025 Jun;136(6):e70048. doi: 10.1111/bcpt.70048.
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Core Data Elements for Pregnancy Pharmacovigilance Studies Using Primary Source Data Collection Methods: Recommendations from the IMI ConcePTION Project.使用初级源数据采集方法进行妊娠药物警戒研究的核心数据元素：来自 IMI ConcePTION 项目的建议。
Drug Saf. 2023 May;46(5):479-491. doi: 10.1007/s40264-023-01291-7. Epub 2023 Mar 28.

本文引用的文献

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Paracetamol use during pregnancy - a call for precautionary action.孕期使用对乙酰氨基酚——呼吁采取预防措施。
Nat Rev Endocrinol. 2021 Dec;17(12):757-766. doi: 10.1038/s41574-021-00553-7. Epub 2021 Sep 23.
2
Is Maternal Use of Paracetamol during Pregnancy Associated with Anogenital Distance in Male Newborns? The Results from the NELA Birth Cohort.母亲在怀孕期间使用扑热息痛是否与男婴的生殖器-肛门距离有关？来自 NELA 出生队列的研究结果。
Int J Environ Res Public Health. 2021 Jun 11;18(12):6338. doi: 10.3390/ijerph18126338.
3
Acetaminophen use during pregnancy and the risk of attention deficit hyperactivity disorder: A causal association or bias?孕期使用对乙酰氨基酚与注意缺陷多动障碍风险：因果关联还是偏倚？
Paediatr Perinat Epidemiol. 2020 May;34(3):309-317. doi: 10.1111/ppe.12615. Epub 2020 Jan 9.
4
Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood.脐带血浆生物标志物与儿童注意缺陷多动障碍和自闭症谱系障碍风险的关联：乙酰氨基酚宫内暴露的相关研究。
JAMA Psychiatry. 2020 Feb 1;77(2):180-189. doi: 10.1001/jamapsychiatry.2019.3259.
5
Prenatal Exposure to Acetaminophen and Risk of ADHD.孕期接触对乙酰氨基酚与注意缺陷多动障碍风险
Pediatrics. 2017 Nov;140(5). doi: 10.1542/peds.2016-3840.
6
Fetal programming of mental health by acetaminophen? Response to the SMFM statement: prenatal acetaminophen use and ADHD.对乙酰氨基酚对心理健康的胎儿编程作用？对母胎医学协会声明的回应：孕期使用对乙酰氨基酚与注意缺陷多动障碍
Expert Opin Drug Saf. 2017 Dec;16(12):1395-1398. doi: 10.1080/14740338.2017.1384812. Epub 2017 Oct 3.
7
Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother-child pairs.孕期母亲使用轻度镇痛药与儿子肛门生殖器距离缩短有关：一项对1027对母婴的队列研究。
Hum Reprod. 2017 Jan;32(1):223-231. doi: 10.1093/humrep/dew285. Epub 2016 Nov 16.
8
Annotations and reflections: pregnancy and paracetamol: methodological considerations on the study of associations between in utero exposure to drugs and childhood neurodevelopment.注释与思考：妊娠与对乙酰氨基酚：关于子宫内药物暴露与儿童神经发育之间关联研究的方法学考量
Basic Clin Pharmacol Toxicol. 2015 Jan;116(1):2-5. doi: 10.1111/bcpt.12322. Epub 2014 Oct 28.
9
Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat.子宫内暴露于轻度镇痛剂是人及大鼠雄性生殖障碍发生的一个危险因素。
Hum Reprod. 2011 Jan;26(1):235-44. doi: 10.1093/humrep/deq323. Epub 2010 Nov 8.