Thangaraju Pugazhenthan, Natha Jondhale Sunil, Venkatesan Sajitha, Tanguturi Yella Sree Sudha
Department of Pharmacology (PT), All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Department of Pediatrics (JSN), All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
J Pediatr Pharmacol Ther. 2022;27(5):457-462. doi: 10.5863/1551-6776-27.5.457. Epub 2022 Jul 6.
The study was started in our institution to analyze the clinical problem and identify the benefits and drawbacks of current practices associated with drug re-dosing after vomitting. Opinions and perspectives from health care professionals from various pediatric hospitals were also gathered to build an effective and systematic protocol.
Survey participants were recruited by using email distribution lists and forums catering to health care. Using this, 2 online surveys were carried out in the window period of 6 months.
Of the 14 responses from the study hospitals that were suitable for analysis, 64.2% reported pediatric patients that vomited after being administered oral medications: 7.1% faced this daily, 35.7% weekly, and 21.4% monthly. When respondents were asked to rate the importance of 8 factors potentially affecting the decision to re-dose, more than half indicated that the patient's vitals and condition (stable, unstable, or critical) were most important (57.4%), followed by time after ingestion (50%), familiarity with medication (42.8%), and formulation of medication (42.8%). Of 43 respondents from other institutions, only 11.9% had a functioning guideline for re-dosing in their institution.
Health care professional respondents to our surveys listed the time between ingestion and vomiting and the condition of the patient as the most important factors in their decision to re-dose the medication.
本研究在我院开展，旨在分析临床问题，明确呕吐后重新给药现行做法的利弊。还收集了各儿科医院医护人员的意见和观点，以制定有效且系统的方案。
通过使用面向医护人员的电子邮件分发列表和论坛招募调查参与者。据此，在6个月的窗口期内进行了2次在线调查。
在来自研究医院的14份适合分析的回复中，64.2%报告有儿科患者在口服药物后呕吐：7.1%的患者每天出现这种情况，35.7%的患者每周出现，21.4%的患者每月出现。当要求受访者对可能影响重新给药决策的8个因素的重要性进行评分时，超过一半的人表示患者的生命体征和状况（稳定、不稳定或危急）最为重要（57.4%），其次是服药后的时间（50%）、对药物的熟悉程度（42.8%）和药物剂型（42.8%）。在来自其他机构的43名受访者中，只有11.9%的机构有重新给药的有效指南。
参与我们调查的医护人员受访者将服药与呕吐之间的时间以及患者的状况列为他们决定重新给药的最重要因素。
