Tosu Aydın Rodi, Kalyoncuoğlu Muhsin, Biter Halil İbrahim, Çakal Sinem, Çakal Beytullah, Selçuk Murat, Çinar Tufan
Department of Cardiology, Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Department of Cardiology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Arch Med Sci Atheroscler Dis. 2022 Jul 7;7:e29-e35. doi: 10.5114/amsad.2022.116662. eCollection 2022.
The current investigation intended to evaluate the correlation between eosinophil-to-lymphocyte ratio (ELR) and the coronary slow-flow phenomenon (CSFP) in patients undergoing elective coronary angiography.
A case-control investigation was conducted on 200 individual CSFP patients and another 200 individuals with normal coronary arteries and who were matched for age, gender, and body mass index. ELR was computed by dividing the number of eosinophils by the number of lymphocytes. Thrombolysis in myocardial infarction frame count was used to determine the CSFP.
The ELR in the CSFP group was substantially greater than in the control group [0.38 (0.28-0.50)] and [0.22 (0.17-0.35)], < 0.001, respectively). With the help of multivariable logistic regression analysis, ELR independently predicted the CSFP presence (odds ratio = 1.040, 95% CI: 1.026-1.053), < 0.001). The effective cutoff point of ELR in predicting CSFP presence was > 0.29 with sensitivity of 77% and specificity of 70%. ELR had better diagnostic accuracy to predict CSFP than either lymphocyte or eosinophil count alone [AUC = 0.746 vs. AUC = 0.687 vs. AUC = 0.687, respectively].
To our knowledge, this was the first investigation to determine the connection between ELR and CSFP. We discovered that individuals with CSFP had higher ELR than those with normal coronary arteries in the control group.
本研究旨在评估择期冠状动脉造影患者中嗜酸性粒细胞与淋巴细胞比值（ELR）与冠状动脉慢血流现象（CSFP）之间的相关性。
对200例CSFP患者和另外200例年龄、性别和体重指数相匹配的冠状动脉正常个体进行病例对照研究。ELR通过嗜酸性粒细胞数除以淋巴细胞数计算得出。采用心肌梗死溶栓帧数来确定CSFP。
CSFP组的ELR显著高于对照组[分别为0.38（0.28 - 0.50）和0.22（0.17 - 0.35），P < 0.001]。通过多变量逻辑回归分析，ELR独立预测CSFP的存在（比值比 = 1.040，95%可信区间：1.026 - 1.053，P < 0.001）。ELR预测CSFP存在的有效截断点> 0.29，敏感性为77%，特异性为70%。ELR预测CSFP的诊断准确性优于单独的淋巴细胞或嗜酸性粒细胞计数[曲线下面积分别为0.746、0.687、0.687]。
据我们所知，这是首次确定ELR与CSFP之间联系的研究。我们发现CSFP患者的ELR高于对照组中冠状动脉正常的个体。
